Biocompatibility of polyetheretherketone for the treatment of orbital bone defects  

作　　者：Rui-Dong Gu Fan Xiao Lin Wang Kai-Jian Sun Lin-Lin Chen 

机构地区：[1]Department of Ophthalmology,the Fourth People’s Hospital of Shenyang,Shenyang 110031,Liaoning Province,China

出　　处：《International Journal of Ophthalmology(English edition)》2020年第5期725-730,共6页国际眼科杂志（英文版）

基　　金：Supported by the Liaoning Province Natural Science Foundation Guidance Program(No.20170520286)。

摘　　要：AIM: To investigate the biocompatibility and therapeutic effects of polyetheretherketone(PEEK) on recovery of a rabbit orbital defect.METHODS: Totally 16 New Zealand rabbits were used to establish an orbital bone defect model and then randomly divided into two groups. PEEK was implanted in the experimental group. The control group was blank, and no substance was implanted. The model rabbits were sacrificed at 4 and 8 wk, and examined by general observations, histology, electron microscopy, Western blotting, and realtime polymerase chain reaction.RESULTS: No infection or rejection occurred after PEEK implantation, and biocompatibility was good. The relative expression of vascular endothelial growth factor(VEGF) protein in the experimental group was significantly higher than that in the control group postoperatively(P<0.05). Bone defect repair in the experimental group was significantly better than that in the control group in the same period and some osteogenesis was observed.CONCLUSION: PEEK has good biocompatibility and efficacy for the treatment of orbital bone defects in a rabbit model.

关 键 词：POLYETHERETHERKETONE HISTOCOMPATIBILITY orbital defect orbital burst fracture three-dimensional printing RABBIT 

分 类 号：R779.12[医药卫生—眼科]