非甾体抗炎药物在牙周炎治疗中应用研究进展  

Research progress in the application of non-steroidal anti-inflammatory drugs in the treatment of periodontitis

作　　者：蔡盈可 潘亚萍[1] CAI Ying-ke;PAN Ya-ping(Department of Periodontology,School and Hospital of Stomatology,China Medical University,Shenyang 110002,China)

机构地区：[1]中国医科大学口腔医学院•附属口腔医院牙周病科,辽宁沈阳110002

出　　处：《中国实用口腔科杂志》2020年第5期314-317,共4页Chinese Journal of Practical Stomatology

基　　金：辽宁省兴辽英才计划项目(XLYC1802129)。

摘　　要：牙周炎是发生在牙周组织的慢性感染性疾病,其主要临床表现为牙龈红肿出血、牙周袋形成、牙齿松动及牙槽骨吸收,是引起成年人牙齿丧失的主要原因之一。近年来,随着对牙周炎发病机制的深入研究发现,前列腺素是牙槽骨吸收强有力的刺激因子,使骨细胞发生破骨性吸收。同时,药物研究发现,非甾体抗炎药物(non-steroidal anti-inflammatory drugs,NSAIDs)能够抑制环氧酶,减少前列腺素的合成,从而产生抗炎、镇痛和成骨效果。因此,在临床上NSAIDs对牙周炎的治疗效果研究成为热点。文章就NSAIDs在牙周炎治疗中应用的研究进展做一综述。Periodontitis is a chronic inflammation that occurs in periodontal tissues,whose mainly manifestation are bleeding and swollen gums,periodontal pocket formation,loose teeth and alveolar bone resorption.Periodontitis is a common oral disease,which is one of the main causes of tooth loss in adults.In recent years,with the study on the periodontitis pathogenesis deepening,researchers have found that prostaglandin is a powerful stimulating factor for alveolar bone resorption,which can cause osteoclastic bone resorption.At the same time,drug research has found that non-steroidal antiinflammatory drugs(NSAIDs)can inhibit the activity of cyclooxygenase and reduce the synthesis of prostaglandins,producing anti-inflammatory,analgesic and osteogenetic effects.Therefore,the therapeutic effects of non-steroidal anti-inflammatory drugs on periodontitis have also been studied in many clinical experimental studies.This review mainly focuses on the application of NSAIDs in the treatment of periodontitis.

关 键 词：牙周炎 非甾体抗炎药物 环氧酶 前列腺素 

分 类 号：R78[医药卫生—口腔医学]