进展期胃癌术前术后免疫调节性T细胞和自然杀伤细胞影响的临床分析  

Clinical Analysis of the Effects of Immunoregulatory T Cells and Natural Killer Cells before and after Operation in Advanced Gastric Cancer

作　　者：吕永昌 唐玉秀 LYU Yong-chang;TANG Yu-xiu(Department of General Surgery,the Second Affiliated Hospital of Guangxi University of Science and Technology,Liuzhou,Guangxi,545006 China)

机构地区：[1]广西科技大学第二附属医院普通外科,广西柳州545006

出　　处：《中外医疗》2020年第5期77-79,共3页China & Foreign Medical Treatment

基　　金：广西壮族自治区卫生和计划生育委员会自筹经费科研课题(Z20180134)。

摘　　要：目的对进展期胃癌患者术前术后免疫调节T细胞与自然杀伤细胞(NK)水平变化及改善方法进行研究。方法方便选取该院2017年1月-2018年12月收治的58例进展期胃癌患者,将其随机分为两组,每组29例。其中,观察组患者给予脾多肽干预,对照组患者未接受脾多肽干预,对两组患者术前与术后免疫调节性T细胞与自然杀伤细胞水平变化进行观察对比。结果与术前相比,观察组患者术后7 d的CD3+、CD4+、CD8+、CD4+/CD8+与NK细胞水平分别为(38.6±5.3)%、(33.2±4.9)%、(28.5±4.1)%、(1.3±0.2)和(18.7±0.7),差异有统计学意义(t=7.596、5.021、4.978、4.029、4.351,差异有统计学意义(P<0.05)),而术后21 d各项指标与术前对比,差异无统计学意义(P>0.05);对照组术前与术后7 d、术后14 d、术后21 d的各项指标变化,差异有统计学意义(P<0.05)。此外,组间对比显示,观察组患者术后14 d和21 d的各项指标结果与对照组相比,差异有统计学意义(P<0.05)。结论进展期胃癌患者手术前后免疫调节性T细胞与NK细胞水平存在明显变化,采用脾多肽能够对患者术后近期免疫功进行改善。Objective To study the changes and improvement methods of immunoregulatory T cells and natural killer cells(NK) in patients with advanced gastric cancer before and after operation. Methods 58 patients with advanced gastric cancer admitted to the hospital from January 2017 to December 2018 were convenienty divided into two groups, 29 in each group.Among them, the patients in the observation group were given spleen polypeptide intervention, and the patients in the control group were not treated with spleen polypeptide. The changes of immunoregulatory T cells and natural killer cells were compared between the two groups. Results The levels of CD3 +, CD4 +, CD8 +, CD4 +/CD8 + and NK cells in the observation group were(38.6±5.3)%,(33.2±4.9)%,(28.5±4.1)%,(1.3±0.2) and(18.7±0.7), respectively, on the 7 th day after the operation, with significant differences(t=7.596, 5.021, 4978, 4.029, 4.351). There were also significant differences in the changes of indicators between the control group before and after 7 d, 14 d and 21 d,the difference was statistically significant(P<0.05). In addition, the comparison between the groups showed that there were significant differences between the observation group and the control group in terms of the indexes 14 d and 21 d after surgery,the difference was statistically significant(P<0.05). Conclusion There are significant changes in the levels of immunoregulatory T cells and NK cells before and after surgery in patients with advanced gastric cancer. The use of spleen polypeptide can improve the recent immune function of patients.

关 键 词：进展期胃癌 根治术 免疫调节性T细胞 自然杀伤细胞 影响 

分 类 号：R735[医药卫生—肿瘤]