CT引导下经皮微波消融治疗作为进展期非小细胞肺癌的维持治疗新手段的效果分析  

Analysis of the Efficacy of CT-guided Percutaneous Microwave Ablation as a New Maintenance Therapy for Advanced Non-small Cell Lung Cancer

作　　者：张杨 ZHANG Yang(Department of Oncology,Pu'er People's Hospital,Pu'er,Yunnan Province,665000 China)

机构地区：[1]普洱市人民医院肿瘤科,云南普洱665000

出　　处：《中外医疗》2020年第5期167-169,共3页China & Foreign Medical Treatment

摘　　要：目的探讨对进展期非小细胞肺癌患者选择CT引导下经皮微波消融方法进行维持治疗后获得的临床效果。方法便利选择该院2016年7月-2018年1月收治的100例进展期非小细胞肺癌患者作为实验对象,针对所有患者临床选择CT引导下经皮微波消融方法展开维持治疗,最终对治疗结果进行观察分析。结果该次研究收治的100例进展期非小细胞肺癌患者,针对100个病灶完成微波消融治疗后,均呈现出程度不同密度变低、空泡化以及肿瘤体积缩小的现象。对患者实施为期1~12个月随访,中位随访<6个月。100例患者中,死亡患者19例,表现出局部进展患者25例。肿瘤最大长径在3.0~4.5 cm,31例患者中,表现出局部进展患者19例(61.29%);肿瘤直径在2.0~3.0 cm 69例患者中,表现出进展患者6例(8.70%);组间比较差异有统计学意义(χ~2=31.557,P<0.05),从而证明肿瘤直径越大,则患者局部进展的概率越显著。完成微波消融术治疗后<3 d,表现出胸腔积液患者9例(9.00%)、气胸患者18例(18.00%)、肺内感染患者8例(8.00%)以及咯血患者10例(10.00%)。结论进展期非小细胞肺癌患者于临床选择CT引导下经皮微波消融方法完成维持治疗后,获得的效果较好,可以使得患者的生存时间获得一定程度的延长,预后情况获得显著改善,最终对进展期非小细胞肺癌患者生存质量的提升可做出保证。Objective To investigate the clinical effect of CT-guided percutaneous microwave ablation for advanced nonsmall cell lung cancer(NSCLC). Methods 100 patients with advanced non-small cell lung cancer admitted to our hospital from July 2016 to January 2018 were convenienty selected as experimental subjects. All patients were treated with CT-guided percutaneous microwave ablation for maintenance, and the results were observed and analyzed. Results For 100 advanced non-small cell lung cancer patients treated in this study, after microwave ablation treatment for 100 lesions, all showed the phenomenon of low density, vacuolation and shrinkage of tumor volume in varying degrees. The patients were followed up for 1 to 12 month with a median follow-up of less than 6 month. Of the 100 patients, 19 died and 25 showed local progression. Among the 31 patients with the maximum tumor diameter 3.0 ~ 4.5 cm, 19 showed local progression(61.29%). Among the 69 patients with tumor diameter2.0 ~ 3.0 cm, 6 showed progression(8.70%). There was a significant difference between the groups(χ~2=31.557,P <0.05), indicating that the larger the tumor diameter, the more significant the probability of local progression. After completing microwave ablation treatment <3 days, 9 patients(9.00%), 18 patients(18.00%) with pneumothorax, 8 patients with pulmonary infection(8.00%), and 10 patients with hemoptysis(10.00%) were shown. Conclusion CT-guided percutaneous microwave ablation for advanced non-small cell lung cancer(NSCLC) patients can achieve better results after maintenance therapy. It can prolong the survival time of patients to a certain extent, improve the prognosis significantly, and ultimately guarantee the improvement of the quality of life of patients with advanced NSCLC.

关 键 词：CT引导 经皮微波消融 进展期非小细胞肺癌 维持治疗 临床效果 

分 类 号：R734[医药卫生—肿瘤]