TP方案化疗序贯三维适形放疗治疗中晚期食管癌的临床疗效及安全性分析  

Clinical Efficacy and Safety Analysis of TP Regimen Sequential Chemotherapy Three-dimensional Conformal Radiotherapy for Advanced Esophageal Cancer

作　　者：刘阳 LIU Yang(Department of Oncology,General Hospital of Jihua Group Corporation,Jilin,Jilin Province,132021 China)

机构地区：[1]吉化集团公司总医院肿瘤科,吉林吉林132021

出　　处：《中外医疗》2020年第8期73-75,共3页China & Foreign Medical Treatment

摘　　要：目的探讨TP方案化疗序贯三维适形放疗治疗中晚期食管癌的临床疗效及安全性。方法方便选取将在该院就诊于2015年1月-2017年8月在该院经病理确定为中晚期食管癌患者102例,随机分成两组,其中51例采用TP方案化疗序贯三维适形放疗称为序贯组,另51例采用TP方案化疗联合三维适形放疗称为联合组,将入组患者的治疗效果及血液系统受到影响的情况进行对比解析。结果疗程结束后序贯组有效率为96.08%,联合组为90.20%,差异无统计学意义(χ~2=1.380,P>0.05)。所有入组患者血液系统检查中出现不同程度的白细胞降低、血红蛋白下降、血小板减少,联合组分别为14例、11例、7例,总计32例,占组数62.75%,序贯组分别为11例、7例、4例,共计22例,占组数43.14%。两组相比差异有统计学意义(χ~2=3.935,P<0.05)。序贯组的患者CD4(27.45±5.48)%、CD8(35.97±7.16)%、CH4/CD8 (0.69±0.18)以及NK细胞数目(20.79±2.49)%均明显高于联合组(38.45±5.98)%、(20.45±6.41)%、(1.31±0.48)、(39.44±3.49)%,差异有统计学意义(P<0.05)。结论对于食管癌患者,采用TP方案化疗序贯三维适形放疗,临床疗效显著,血液系统异常反应较低,效果理想。Objective To explore the clinical efficacy and safety of sequential three-dimensional conformal radiotherapy for TP chemotherapy in the treatment of advanced esophageal cancer. Methods Convenient select A total of 102 patients with advanced esophageal cancer diagnosed by pathology in the hospital from January 2015 to August 2017 were randomly divided into two groups, of which 51 patients received sequential three-dimensional conformal chemotherapy with TP chemotherapy radiotherapy as the sequential group, and the other 51 patients who received TP regimen chemotherapy combined with three-dimensional conformal radiotherapy as the combined group. The treatment effect and blood system of affected patients were compared and analyzed. Results After the end of the treatment course, the effective rate was 96.08%in the sequential group and 90.20% in the combined group, and the difference was not statistically significant(χ~2=1.380, P>0.05). All patients in the study showed different degrees of leukopenia, hemoglobin, and thrombocytopenia in the blood system examination. The combined group had 14 cases, 11 cases, and 7 cases, respectively, with a total of 32 cases accounting for 62.75% of the group and in the sequential group of 11 cases, 7 cases and 4 cases, with a total of 22 cases,accounting for 43.14% of the group number. The difference between the two groups was statistically significant(χ~2=3.935, P<0.05). Patients in the sequential group had significantly higher CD4^+(27.45±5.48)%, CD8^+(35.97±7.16)%, CH4/CD8(0.69±0.18), and NK cell numbers(20.79±2.49)% than those in the combined group(38.45±5.98) and(20.45±6.41)%,(1.31±0.48),(39.44±3.49)%, and the differences were statistically significant(P<0.05). Conclusion For patients with esophageal cancer,sequential three-dimensional conformal radiotherapy with TP chemotherapy has significant clinical effects, lower abnormal blood system response, and ideal results.

关 键 词：TP方案化疗 序贯 三维适形放疗 临床疗效 安全性分析 

分 类 号：R735.1[医药卫生—肿瘤]