连芍灌肠剂保留灌肠治疗轻中度溃疡性结肠炎的临床效果  

Clinical effect of retention enema with Lianshao Enema Agent in the treatment of mild and moderate ulcerative colitis

作　　者：洪子夫[1] 贾菲[1] 袁亮[1] 李峨[1] 何颖华[1] 曲牟文[1] 冯丽鹏[1] HONG Zifu;JIA Fei;YUAN Liang;LI E;HE Yinghua;QU Mouwen;FENG Lipeng(Department of Proctology,Guang'anmen Hospital of China Academy of Chinese Medical Sciences,Beijing100053,China)

机构地区：[1]中国中医科学院广安门医院肛肠科,北京100053

出　　处：《中国医药导报》2020年第13期160-163,共4页China Medical Herald

基　　金：北京市中医药科技项目(JJ2011-85)。

摘　　要：目的探讨连芍灌肠剂保留灌肠治疗溃疡性结肠炎(UC)的临床效果。方法选择广安门医院肛肠科2013年1月~2014年12月轻、中度UC患者40例,按随机数字表法将其分为治疗组和对照组,每组各20例。但治疗组有1例患者在灌肠后出现明显的直肠刺激症状,自动退出,故治疗组纳入19例。两组均口服美沙拉秦肠溶片1 g,3次/d,治疗组加用连芍灌肠剂保留灌肠,每晚1次,每日一剂。疗程均为3周。观察两组临床有效率,治疗前后中医证候积分以及中医症状评分。结果治疗组有效率高于对照组,差异有统计学意义(P<0.05)。治疗前两组患者中医证候积分比较,差异无统计学意义(P>0.05),治疗后两组患者中医证候积分较治疗前降低,且治疗组低于对照组,差异均有统计学意义(均P<0.05)。治疗前两组患者中医症状评分比较,差异无统计学意义(P>0.05);治疗后两组患者中医症状评分较治疗前降低,且治疗组黏液血便、腹痛、里急后重、肛门烧灼症状评分低于对照组,差异均有统计学意义(均P<0.05);两组患者治疗后腹泻症状评分比较,差异无统计学意义(P>0.05)。结论连芍灌肠剂保留灌肠治疗轻、中度UC效果确切,尤其是在改善临床症状方面,疗效显著,且使用方便,值得推广应用。Objective To investigate the clinical efficacy of Lianshao Enema Agent retention enema in the treatment of ulcerative colitis(UC).Methods A total of 40 cases of mild and moderate UC patients from January 2013 to December 2014 in the Department of Proctology,Guang'anmen Hospital were selected and divided into the treatment group and the control group according to the random number table method,with 20 cases in each group.However,one patient in the treatment group showed obvious rectal stimulation symptoms after enema and withdrew automatically,so 19 cases were included in the treatment group.Both groups took Mesalazine Enteric-coated Tablets orally for 1 g,3 times/d.In the treatment group,the retention enema was added with the Lianshao Enema Agent,once a night,once a day.The treatment course was 3 weeks.Clinical efficacy,traditional Chinese medicine syndrome score and traditional Chinese medicine symptom score before and after treatment were observed.Results The effective rate of the treatment group was higher than that of the control group,and the difference was statistically significant(P<0.05).There was no significant difference in traditional Chinese medicine syndrome scores between the two groups before treatment(P>0.05).After treatment,the traditional Chinese medicine syndrome scores of the two groups were lower than those before treatment,and the treatment group was lower than the control group,with statistically significant differences(all P<0.05).There was no significant difference in traditional Chinese medicine symptom score between the two groups before treatment(P>0.05).After treatment,the traditional Chinese medicine symptom scores in the two groups were lower than those before treatment,and the scores of mucus blood stools,abdominal pain,tenesmus and anal burning symptoms in the treatment group were lower than those in the control group,with statistically significant differences(all P<0.05).There was no statistically significant difference in diarrhea symptom scores between the two groups after trea

关 键 词：连芍灌肠剂 溃疡性结肠炎 保留灌肠 临床疗效 

分 类 号：R574.62[医药卫生—消化系统]