肿瘤坏死因子样配体1A在炎症性肠病免疫调控中的作用  

Role of tumor necrosis factor-like ligand 1 aberrance in the immune regulation of inflammatory bowel disease

作　　者：王冬[1] 罗雨欣 张晓岚[1] Wang Dong;Luo Yuxin;Zhang Xiaolan(Department of Gastroenterology,the Second Hospital of Hebei Medical University,Shijiazhuang 050035,China)

机构地区：[1]河北医科大学第二医院消化内科,石家庄050035

出　　处：《中国综合临床》2020年第3期284-288,共5页Clinical Medicine of China

基　　金：国家自然科学基金项目(81370501)。

摘　　要：炎症性肠病包括溃疡性结肠炎和克罗恩病,目前多认为其发病机制是环境因素作用于遗传易感者,在肠道菌群的参与下,启动了难以停止的、发作与缓解交替的肠道免疫反应。然而,其发病机制尚不十分明确,因此,进一步探讨和阐明炎症性肠病的发病机制对于寻找新的治疗方法具有重要的意义。肿瘤坏死因子样配体1A(tumor necrosis factor-like ligand 1 aberrance,TL1A)是新近发现的一种肿瘤坏死因子家族新成员,是炎症性肠病的易感基因。TL1A在黏膜炎症的固有免疫和适应性免疫之间起到了关键的调控和连接作用,从而在炎症性肠病中发挥重要作用。现将TL1A在炎症性肠病免疫调控机制中的作用进行综述。Inflammatory bowel disease includesulcerative colitis and Crohn′s disease.At present,it is generally believed that the pathogenesis of inflammatory bowel disease is that environmental factors act on the genetic susceptible.With the participation of intestinal flora,it starts the intestinal immune response which is difficult to stop and alternates between attack and remission.However,the pathogenesis of IBD is not very clear,so it is important to further explore and clarify the pathogenesis of IBD for the search of new treatment.Tumor necrosis factor-like ligand 1 aberrance(TL1A)is a newly discovered new member of tumor necrosis factor family and a susceptible gene of inflammatory bowel disease.TL1A plays a key role in the regulation and connection between innate immunity and adaptive immunity of mucosal inflammation,and thus plays an important role in inflammatory bowel disease.This article reviews the role of TL1A in the immune regulatory mechanism of inflammatory bowel disease.

关 键 词：炎症性肠病 单核苷酸多态性 固有免疫 适应性免疫 肿瘤坏死因子样配体1A 

分 类 号：R57[医药卫生—消化系统]