首发精神分裂症女性患者基于Stroop范式的近红外光谱成像的脑血流空间特征分析  

Spatial characteristics of cerebral blood flow in female patients with first-episode schizophrenia by Stroop's near infrared spectroscopy

作　　者：杨和增 洪晓虹[1] Yang Hezeng;Hong Xiaohong(Mental Health Faculty,Medical College of Shantou University,Shantou 515041,China;Department of Acute Intervention,Shenzhen Kangning Hospital,Shenzhen 515063,China)

机构地区：[1]汕头大学医学院精神卫生系,515041 [2]深圳市康宁医院急性干预科,515063

出　　处：《神经疾病与精神卫生》2020年第2期132-136,共5页Journal of Neuroscience and Mental Health

摘　　要：目的探讨首发精神分裂症女性患者以Stroop范式的近红外光谱成像(NIRS)的脑血流空间特征。方法前瞻性连续纳入2018年1月至2019年12月深圳市康宁医院急性干预科住院的女性首次发作的精神分裂症患者9例,并纳入观察组,同时纳入年龄、受教育年限与观察组相匹配的健康者作为对照组(9例)。以Stroop测试为范式,行NIRS检测,检测时间共74 s,记录NIRS的数据。其中前面10 s为基线期,任务期共64 s,计算相对于基线期的平均氧合血红蛋白(OxyHb)水平,分析NIRS的空间特征。观察组给予奥氮平[平均剂量(17.78±2.92)mg/d]治疗4周,治疗前后各检测1次NIRS,对照组检测1次。结果观察组患者治疗前通道17、18平均OxyHb水平为0.02(-0.02,0.18)、0.04(-0.07,4.11)mmol/L,均高于对照组[-0.22(-0.33,0.04)、-0.35(-0.69,-0.02)mmol/L],通道20治疗前为-0.17(-0.32,0)mmol/L,低于对照组[0.08(-0.08,0.34)mmol/L],差异均有统计学意义(均P<0.05);通道17、18、20治疗后平均OxyHb水平分别为-0.05(-0.21,0.04)、-0.10(-0.24,0.01)、-0.02(-0.21,0.11)mmol/L,与对照组比较,差异均无统计学意义(均P>0.05)。结论女性精神分裂症患者治疗前存在前额叶右腹部中间区负激活及左中间腹外侧区正激活的情况,治疗后有改善。Objective To investigate the spatial characteristics of cerebral blood flow in female patients with first-episode schizophrenia by Stroop's near infrared spectroscopy(NIRS).Methods A total of 9 female first-episode schizophrenic patients consecutively admitted in the Department of Acute Intervention of Shenzhen Kangning Hospital from January 2018 to December 2019 were recruited as the observation group.At the same time,9 healthy controls matched in age and education level were enrolled as the control group.Taking Stroop test as the paradigm,NIRS was detected for 74 s,and the data of NIRS was recorded.The first 10 s was set as the baseline period,and the last 64 s was the task period.The average oxyhemoglobin(OxyHb)level relative to the baseline period is calculated,and the spatial characteristics of NIRS are analyzed.The observation group was treated with olanzapine[average dose(17.78±2.92)mg/d]for 4 weeks,and NIRS was detected before and after treatment respectively,and the control group was detected once.Results The average OxyHb value(mmol/L)of the channels 17 and 18 of the patients before treatment were 0.02(-0.02,0.18)and 0.04(-0.07,4.11),which were significantly higher than those of the control group[-0.22(-0.33,0.04)and-0.35(-0.69,-0.02)].While the OxyHb of channel 20 of the patients before treatment was-0.17(-0.32,0),which was significantly lower than that of the control group[0.08(-0.08,0.34)].All the differences were statistically significant(P<0.05).After treatment,the OxyHb of channels 17,18 and 20 of the patients were[-0.05(-0.21,0.04)],[-0.10(-0.24,0.01)]and[-0.02(-0.21,0.11)],with no significant differences from the control group(P>0.05).Conclusions There was negative activation in the middle area of the right abdomen and positive activation inleft middle ventrolateral area of prefrontal lobe in the patient group before treatment,which was improved after treatment.

关 键 词：精神分裂症 STROOP 近红外光谱成像 空间特征 女性 

分 类 号：R749.3[医药卫生—神经病学与精神病学]