白内障超声乳化手术中台盼蓝囊膜染色对角膜内皮细胞影响的Meta分析  

A Meta-analysis of the effect of trypan blue capsule staining on corneal endothelial cells in phacoemulsification

作　　者：苏扬 符敏[2] 易果果 Yang Su;Min Fu;Guo-Guo Yi(Second Institute of Clinical Medicine, Southern Medical University, Guangzhou 510515, Guangdong Province, China;Department of Ophthalmology, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, Guangdong Province, China;Department of Ophthalmology, the Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou 510655, Guangdong Province, China)

机构地区：[1]南方医科大学第二临床医学院,中国广东省广州市510515 [2]南方医科大学珠江医院眼科,中国广东省广州市510280 [3]中山大学附属第六医院眼科,中国广东省广州市510655

出　　处：《国际眼科杂志》2020年第6期1016-1021,共6页International Eye Science

摘　　要：目的:系统评价白内障超声乳化手术中台盼蓝囊膜染色对角膜内皮细胞的影响。方法:采用Cochrane系统评价的方法,计算机检索中国知网、万方、维普、SinoMed、PubMed、SpringerLink、Clinicalkey、Medline、Cochrane图书馆、Web of Science、OVID、Embase数据库中关于白内障超声乳化手术中使用台盼蓝进行囊膜染色的随机对照试验(RCTs),检索时限均为建库至2019-04,采用Revman5.3、R 3.7对纳入文献进行Meta分析。结果:共纳入8篇RCTs(378例)。结果显示0.02%、0.06%或0.1%浓度台盼蓝囊膜染色组(193例)与未染色或安慰剂染色组(185例)角膜内皮细胞丢失数均无差异[术后1mo内(WMD=-10.47,95%CI:-26.44~5.61,P=0.20);术后1mo后(WMD=-60.72,95%CI:-170.92~49.49,P=0.28)];两组术后1mo角膜内皮六角形细胞丢失比例无差异(WMD=0.50,95%CI:-2.09~3.09,P=0.71);中央角膜厚度(CCT)无差异(WMD=3.10,95%CI:-5.77~11.98,P=0.49);角膜变异系数(CV)无差异(WMD=-1.00,95%CI:-2.86~0.86,P=0.29)。结论:白内障超声乳化手术中应用0.02%、0.06%或0.1%浓度台盼蓝囊膜染色对角膜内皮细胞数量及功能无明显影响。·AIM:To systematically evaluate the effect of trypan blue capsule staining on corneal endothelial cells in phacoemulsification.·METHODS:RCTs on the use of trypan blue for capsular staining in phacoemulsification were retrieved from China Knowledge Network(CNKI),Wanfang Database,Weipu Database,SinoMed,PubMed,SpringerLink,Clinicalkey,Medline,Cochrane Library,Web of Science,OVID,Embase.The search time was from the establishment of the databases to April 2019.The Meta-analysis of the included literature was made by Revman 5.3 and R 3.7.·RESULTS:Eight trials included 378 eyes were selected.Meta-analysis showed that the number of corneal endothelial cell loss between 0.02%,0.06%or 0.1%trypan blue capsule staining group(193 eyes)and non-stained or placebo staining group(185 eyes)changed without statistical significance[Within 1mo after operation(WMD=-10.47,95%CI=-26.44-5.61,P=0.20);1mo after operation(WMD=-60.72,95%CI=-170.92-49.49,P=0.28)].The percentage of corneal endothelial hexagonal cell loss at 1mo after operation changed without statistical significance(WMD=0.50,95%CI=-2.09-3.09,P=0.71).The central corneal thickness(CCT)at 1mo after operation changed without statistical significance(WMD=3.10,95%CI=-5.77-11.98,P=0.49).The coefficient of variation(CV)changed without statistical significance(WMD=-1.00,95%CI=-2.86-0.86,P=0.29).·CONCLUSION:0.02%,0.06%or 0.1%trypan blue capsule staining in phacoemulsification have no significant effect on the number and function of corneal endothelial cells.

关 键 词：白内障 超声乳化手术 台盼蓝 角膜内皮细胞 META分析 

分 类 号：R73[医药卫生—肿瘤]