Neuropsychopharmacological profile of Astragalus membranaceous var.mongholicus  

作　　者：Aldarmaa Jalsrai Avijit Biswas Nikolai I.Suslov Joseph V.Martin 

机构地区：[1]Institute of Traditional Medicine and Technology,495 Ulaanbaatar-36,Mongolia [2]Biology Department,Rutgers University,315 Penn St.,Camden,NJ 08102,USA [3]Research Institute of Pharmacology and Regenerative Medicine,3 Lenin Ave.,Tomsk 634028,Russia [4]Center for Computational and Integrative Biology,Rutgers University,Camden,NJ 08102,USA

出　　处：《Journal of Traditional Chinese Medical Sciences》2019年第3期254-262,共9页中医科学杂志（英文）

基　　金：The project was funded by the Mongolian Foundation of Science and Technology of Mongolia(17AT05IN324,AJ).Parts of the work were supported by the National Science Foundation(IOS-0724962(JVM)and DBI-0421079(JVM)).

摘　　要：Objective:To clarify the neuropharmacological profile of the Mongolian vetch,Astragalus mongholicus(Astragalus membranaceous var.mongholicus;synonym:A.mongholicus),extracts were evaluated for behavioral effects in rats and mice.Methods:An aqueous extract of A.mongholicus was made by boiling roots from freshlycollected plants in 2.5 volumes(w/v)of water for 60 minutes.An ethanol extract was made by incubating in 70%ethanol for 5 days at 25
C.Effects of the aqueous extracts were evaluated in a forced swimming assessment of antidepressant effects,a hole-board test of exploratory behavior,an analysis of inhibition of aggression following electrical stimulation and influences on amnesia resulting from electroshock.Furthermore,effects of ethanol extracts of A.mongholicus were assessed on L-tryptophan induced twitches(indicating serotonin-mediated effects)and on hypothermia induced by apomorphine(indicating dopamine-mediated interactions)in mice.Results:Per os(PO)administration of the aqueous decoction of the vetch to rats increased the response in a forced swimming test as reflected in wheel rotations.However,the decoction had no significant effect on the exploratory behavior of rats in the hole-board test.Acute PO administration of the aqueous extract of A.mongholicus decreased the threshold for aggressive behavior and this effect persisted with subchronic administration.Chronic administration of the plant extract suppressed aggression of rats.An ethanol extract of A.mongholicus showed an antiserotoninergic action and had a significant influence on the hypothermia induced by apomorphine.Conclusion:A.mongholicus has a variety of potent psychotropic actions,suggesting influences on diverse neurotransmitter systems.

关 键 词：ANTIDEPRESSANT ANXIOLYTIC Mongolian vetch NOOTROPIC Psychotropic effect 

分 类 号：R285.5[医药卫生—中药学]