恶性淋巴瘤患者自体造血干细胞移植治疗后的生存及预后因素分析  

Analysis of Survival and Prognosis Factors in Patients with Malignant Lymphoma after Autologous Hematopoietic Stem Cell Transplantation

作　　者：王清松[1] 王凌云[1] 王萍[1] WANG Qingsong;WANG Lingyun;WANG Ping(West China Hospital,Chengdu,610041)

机构地区：[1]四川大学华西医院,610041

出　　处：《实用癌症杂志》2020年第5期756-759,共4页The Practical Journal of Cancer

基　　金：2015年度CMB护理青年教师科研基金项目(编号:13-168-201507)。

摘　　要：目的探讨恶性淋巴瘤患者自体造血干细胞移植治疗后的生存及预后因素。方法收集72例进行自体造血干细胞移植治疗的恶性淋巴瘤患者临床资料,另收集同期收治的采用单纯化疗方案治疗的50例恶性淋巴瘤患者临床资料,所有患者均获得3~63个月随访,统计其生存情况,并分析自体造血干细胞移植治疗患者预后影响因素。结果所有患者均获得有效随访,截止随访时间,自体造血干细胞移植治疗患者存活率高于单纯化疗患者(P<0.05)。单因素分析显示,自体造血干细胞移植治疗生存组骨髓侵犯、B症状、IPI评分、移植前状态、乳酸脱氢酶(LDH)水平与死亡组存在差异(P<0.05)。COX比例风险回归模型显示,移植前状态是否为完全缓解(CR)是影响自体造血干细胞移植治疗患者预后的独立因素(P<0.05)。结论自体造血干细胞移植治疗可改善恶性淋巴瘤患者生存状况,其预后与移植前状态有关。Objective To explore the survival and prognosis factors in patients with malignant lymphoma after autologous hematopoietic stem cell transplantation.Methods The clinical data of 72 patients with malignant lymphoma who underwent autologous hematopoietic stem cell transplantation were collected.The clinical data of 50 patients with malignant lymphoma treated with chemotherapy alone during the same period were collected.All patients were given 3~63 months of follow-up,and the survival status was counted,and the influencing factors for prognosis were analyzed among patients with autologous hematopoietic stem cell transplantation.Results All patients had effective follow-up.By the deadline of follow-up,the survival rate of patients with autologous hematopoietic stem cell transplantation was higher than that of patients with chemotherapy alone(P<0.05).Univariate analysis showed that there were differences in the bone marrow involvement,B symptoms,IPI score,pre-transplant status and lactate dehydrogenase(LDH)level in survival group with autologous hematopoietic stem cell transplantation compared with those in death group(P<0.05).COX proportional risk regression model showed that whether pre-transplant status was complete remission(CR)was an independent factor affecting the prognosis of patients with autologous hematopoietic stem cell transplantation(P<0.05).Conclusion Autologous hematopoietic stem cell transplantation can improve the survival status of patients with malignant lymphoma,and its prognosis is related to the pre-transplant status.

关 键 词：恶性淋巴瘤 自体造血干细胞移植 生存情况 预后影响因素 

分 类 号：R733.4[医药卫生—肿瘤]