改良Ivor-Lewis手术对食管癌患者肺功能及炎症细胞因子的影响  

Effects of Modified Ivor-lewis Surgery on Pulmonary Function and Inflammatory Cytokines in Patients with Esophageal Cancer

作　　者：赵磊 张新忠 梁保华 ZHAO Lei;ZHANG Xinzhong;LIANG Baohua(Kaifeng People's Hospital,Kaifeng,475000)

机构地区：[1]河南省开封市人民医院,475000

出　　处：《实用癌症杂志》2020年第5期804-807,共4页The Practical Journal of Cancer

摘　　要：目的探讨改良Ivor-Lewis手术对食管癌患者肺功能及炎症细胞因子的影响。方法选取食管癌患者86例,随机分为2组,对照组应用常规开放手术治疗,研究组应用改良Ivor-Lewis手术治疗。比较2组患者手术时间、住院时间、淋巴结清扫数量、出血量、肺功能、肿瘤坏死因子-α(TNF-α)、白介素细胞-10(IL-10)、白介素细胞-8(IL-8)、白介素细胞-6(IL-6)因子浓度、并发症。结果研究组手术时间、住院时间短于对照组(P<0.05);淋巴结清扫数量多于对照组(P<0.05);出血量少于对照组(P<0.05)。研究组肺功能高于对照组(P<0.05)。研究组TNF-α、IL-10、IL-8、IL-6因子浓度低于对照组(P<0.05)。研究组并发症少于对照组(P<0.05)。结论食管癌治疗中,改良Ivor-Lewis手术的最终治疗效果令人满意,值得在临床上广泛推广与应用。Objective To investigate the effects of modified Ivor-Lewis surgery on lung function and inflammatory cytokines in patients with esophageal cancer.Methods 86 patients with esophageal cancer were randomly divided into 2 groups.The control group received routine open surgery and the study group received modified Ivor-Lewis surgery.The operation time,hospitalization time,lymph node dissection,blood loss,lung function,tumor necrosis factor-α(TNF-α),interleukin-10(IL-10),interleukin-8(IL-8),interleukin-6(IL-6)factor concentration,and complications were compared between the 2 groups.Results The operation time and hospitalization time of the study group were shorter than those of the control group(P<0.05).The number of lymph node dissection in the study group was higher than that of the control group(P<0.05).The bleeding volume of the study group was less than that of the control group(P<0.05).The lung function of the study group was higher than that of the control group(P<0.05).The concentrations of TNF-α,IL-10,IL-8 and IL-6 in the study group were lower than those of the control group(P<0.05).The complication of the study group was less than that of the control group(P<0.05).Conclusion In the treatment of esophageal cancer,the final therapeutic effect of modified Ivor-Lewis surgery is satisfactory,and it is worthy of widespread promotion and application in clinical practice.

关 键 词：改良Ivor-Lewis手术 食管癌 肺功能 白介素细胞-8 白介素细胞-6 

分 类 号：R735.1[医药卫生—肿瘤]