中性粒细胞胞外诱捕网与肿瘤相关研究进展  

Research progress on neutrophil extracellular traps in tumor

作　　者：徐亦鸣 应可净[1] XU Yiming;YING Kejing(Department of Respiratory Medicine,Sir Run Run Shaw Hospital,Zhejiang University School of Medicine,Hangzhou 310016,China)

机构地区：[1]浙江大学医学院附属邵逸夫医院呼吸内科,浙江杭州310016

出　　处：《浙江大学学报（医学版）》2020年第1期107-112,共6页Journal of Zhejiang University(Medical Sciences)

基　　金：国家自然科学基金(81970049);国家重大科研仪器研制项目(31627801)。

摘　　要：中性粒细胞胞外诱捕网(NET)是一种来源于中性粒细胞的由DNA骨架及多种镶嵌于其上的活性蛋白组成的细胞外纤维网状结构。NET除了发挥杀菌作用,与免疫性疾病、血栓、肿瘤等多种疾病都有密切关联。近年来,多项研究表明NET在多种肿瘤中高表达,且肿瘤及其微环境可以促进NET的产生,而NET也参与多种肿瘤的发生发展,与肿瘤增殖、转移及相关血栓形成均密切相关,这也为肿瘤的临床诊治提供了新的思路。本文主要阐述NET与肿瘤相关的研究进展,并对其临床应用价值作一展望。Neutrophil extracellular traps(NET)is neutrophil-derived extracellular fiber web-like structure,composed of DNA scaffold studded with various active proteins.In addition to its bactericidal effect,NET is closely related to various diseases including immune disease,thrombosis and tumor.Recently,lots of researches have shown that NET is highly expressed in a variety of tumors,tumor cells and microenvironment can promote NET formation,whereas NET participates in tumor progression as well,and is closely related to tumor proliferation,metastasis and thrombosis,which provides new clinical thinking in tumor diagnosis as well as treatment indeed.This review will focus on the research progress of NET and tumor,meanwhile make a prospect for its clinical application value.

关 键 词：肿瘤形成过程 中性粒细胞胞外诱捕网 肿瘤/细胞增殖 肿瘤转移 肿瘤复发 血栓形成 综述 

分 类 号：R730.23[医药卫生—肿瘤]