OSAS和NSCLC的细胞学和遗传学特点  

Cytological and Genetic Characteristics of OSAS and NSCLC

作　　者：林庆艳[1] 孟宪锋[2] 尹虹雷[1] LIN Qingyan;MENG Xianfeng;YIN Honglei(Department of Respiratory Medicine,Heilongjiang Provincial Hospital/Heilongjiang Provincial Hospital Affiliated to Harbin University of Technology,Harbin Heilongjiang 150001,China;Imaging Department)

机构地区：[1]黑龙江省医院/哈尔滨工业大学附属黑龙江省医院呼吸内科,黑龙江哈尔滨150001 [2]黑龙江省医院/哈尔滨工业大学附属黑龙江省医院医院影像科,黑龙江哈尔滨150001

出　　处：《中国卫生标准管理》2020年第9期34-35,共2页China Health Standard Management

基　　金：黑龙江省应用技术研究与开发计划项目[名称:阻塞性睡眠呼吸暂停(OSA)相关肺癌易感基因序列植入芯片技术研发;编号:GZ19C01]。

摘　　要：目的探讨OSAS和NSCLC和遗传学特点。方法选取20例阻塞性睡眠呼吸暂停综合征患者作为OSAS(obstructive sleep apnea syndrome,阻塞性睡眠呼吸暂停综合征)组,20例非小细胞肺癌患者作为NSCLC(non-small cell lung cancer,非小细胞肺癌)组,20例健康者作为对照组,纳入试验时间为2018年7月-2019年7月,对比三组研究对象的IL-6(interleukin-6,白细胞介素-6)水平和HIF-1α(hypoxia inducible factor-1α,缺氧诱导因子-1α)水平。结果 OSAS组和NSCLC组的IL-6水平和HIF-1α水平均大于对照组,差异显著有统计学意义(P <0.05)。结论临床诊断对IL-6和HIF-1α进行早期检测对控制病情发展有十分重要的临床意义。Objective To investigate the cytological and genetic characteristics of obstructive sleep apnea syndrome and non-small cell lung cancer. Methods Twenty patients with OSAS were selected as the OSAS group, 20 patients with NSCLC were selected as the NSCLC group, and 20 healthy patients were used as the control group. The trial period was from July 2018 to July 2019. The levels of IL-6 and HIF-1α were compared between the three groups of subjects. Results The levels of IL-6 and HIF-1α in the OSAS and NSCLC groups were larger than those in the control group, and the differences were statistically significant(P < 0.05). Conclusion Early diagnosis of IL-6 and HIF-1α in clinical diagnosis is of great clinical significance in controlling the development of the disease.

关 键 词：阻塞性睡眠呼吸暂停综合征 非小细胞肺癌 白细胞介素-6 缺氧诱导因子(HIF) 细胞学 遗传学 

分 类 号：R766[医药卫生—耳鼻咽喉科]