血清心肌酶、心肌损伤标志物与急性脑梗死病情严重程度、梗死部位的关系  

Relationship Between Serum Myocardial Enzymes and Myocardial Injury Markers with the Severity of Acute Cerebral Infarction and the Location of Infarction

作　　者：程映秋[1] 王建林[1] 张云茜[1] 罗丽华[1] 范云虎[1] CHENG Ying-qiu;WANG Jian-lin;ZHANG Yun-qian;LUO Li-hua;FAN Yun-hu(Department of Neurology,the Second People's Hospital of Yunnan Province,Kunming 650021,Yunnan,China)

机构地区：[1]云南省第二人民医院神经内科,云南昆明650021

出　　处：《医学信息》2020年第10期117-119,共3页Journal of Medical Information

摘　　要：目的探讨血清心肌酶、心肌损伤标志物与急性脑梗死病情严重程度、梗死部位的关系。方法回顾性分析2017年7月~2018年6月我院住院的162例急性脑梗死患者的临床资料,按照脑部血液供应情况及头颅影像学资料分为前循环脑梗死组108例和后循环脑梗死组54例,前循环脑梗死组患者根据NIHSS评分分为NIHSS评分<8分患者40例和NIHSS评分≥8分患者68例,比较各组心肌酶及心肌损伤标志物水平。结果后循环脑梗死组CK、CK-MB、AST、LDH、MYO、cTNT水平均高于前循环脑梗死组,差异有统计学意义(P<0.05);后循环脑梗死组CK、AST、LDH、CK-MB、MYO、cTNT异常占比高于前循环脑梗死组,差异有统计学意义(P<0.05),其中各项指标中以cTNT异常占比最多。NIHSS评分≥8分患者CK、AST、LDH、CKMB、MYO、cTNT水平高于NIHSS评分<8分患者,差异有统计学意义(P<0.05)。结论心肌酶及心肌损伤标志物水平与脑梗死的部位及病情严重程度有关,其中后循环及病情重的脑梗死患者心肌酶及心肌损伤标志物升高明显,为并发心脏损害的高风险人群。Objective To investigate the relationship between serum myocardial enzymes, myocardial injury markers and the severity of acute cerebral infarction and the location of infarction.Methods Retrospectively analyzed the clinical data of 162 patients with acute cerebral infarction in our hospital from July 2017 to June 2018. According to the blood supply of the brain and cranial imaging data, they were divided into anterior circulation cerebral infarction group 108 cases and posterior circulation brain 54 cases of infarction group,according to NIHSS score, patients in the anterior circulation cerebral infarction group were divided into 40 patients with NIHSS score <8 points and 68 patients with NIHSS score ≥ 8 points. The levels of myocardial enzymes and myocardial injury markers in each group were compared.Results The levels of CK, CK-MB, AST, LDH, MYO, cTNT in the posterior circulation cerebral infarction group were higher than those in the anterior circulation cerebral infarction group,the difference was statistically significant(P<0.05);The abnormal proportion of CK, AST, LDH, CK-MB, MYO, cTNT in the posterior circulation cerebral infarction group was higher than that in the anterior circulation cerebral infarction group,the difference was statistically significant( P<0.05).Among all indicators, c TNT anomalies accounted for the most. The CK, AST, LDH, CK-MB, MYO and cTNT levels of patients with NIHSS score ≥ 8 were higher than those with NIHSS score <8,the difference was statistically significant(P<0.05).Conclusion The levels of myocardial enzymes and myocardial injury markers are related to the location of cerebral infarction and the severity of the disease. Among the patients with posterior circulation and severe cerebral infarction,myocardial enzymes and myocardial injury markers are significantly increased, which is a high-risk group of complicated heart damage.

关 键 词：脑梗死 心肌酶 心肌损伤标志物 

分 类 号：R743.3[医药卫生—神经病学与精神病学]