乳头状胶质神经元肿瘤临床病理分析  

Clinicopathological analysis of papillary glioneuronal tumors

作　　者：刘立娜[1] 仉立佳 苏雪豪 LIU Li-na(Pathology department,Beijing Fengtai Hospital,Beijing,100071,China)

机构地区：[1]北京丰台医院病理科,北京100071

出　　处：《齐齐哈尔医学院学报》2020年第3期282-285,共4页Journal of Qiqihar Medical University

摘　　要：目的分析乳头状胶质神经元肿瘤(papillary glioneuronal tumors,PGNT)的临床表现、影像特征、病理特点及预后疗效。方法选择2015年1月-2018年12月北京丰台医院神经外科收入院,经病理证实为乳头状胶质神经元肿瘤患者8例,回顾性分析肿瘤患者的临床表现、影像资料、病理特点及预后疗效。结果 8例患者中2例以头疼起病,6例以癫痫起病;MRI表现均为T1WI低信号,T2WI高信号,增强扫描不均匀强化;其中1例患者伴有散在钙化;WHO肿瘤分级为I级,肿瘤细胞单层或双层围绕血管排列成乳头状结构,肿瘤细胞表达GFAP、olig-2等神经胶质细胞标记物,同时表达NeuN、syn、NSE等神经元标记物;术后MIR显示肿物全部切除,随访2~60个月,均无复发。结论乳头状胶质神经元肿瘤是一种罕见的混合性胶质神经元肿瘤,认为起源于神经胶质前体细胞及神经干细胞,发病率较少,预后较好。Objective To investigate the clinical,radiological,and pathological characteristics of papillary glioneuronal tumors(PGNT),and the prognosis and efficacy.Methods Eight patients with pathologically confirmed PGNT who had undergone surgery in Beijing Fengtai hospital during January 2015 and December 2018 were included.The clinical,radiological,and pathological data and outcomes were retrospectively analyzed.Results Of these 8 patients,two cases onset due to headache and six cases onset due to epilepsy.MRI showed T1WI hypointense,T2WI hyperintense and inhomogeneous enhancement on enhanced scans.One patient complicated with sporadic calcifications.Most PGNT corresponded histological to WHO grade I.A single or double layer of tumor cells formatted a papillary structure around blood vessels.Tumor cells expressed both glial markers(GFAP,Olig-2)and neuronal markers(NeuN,Syn,NSE).MRI image showed that the 8 patients got complete resection,and were followed-up for 2 to 60 months,none recurrence records were collected.Conclusions PGNT is a rare hybrid glial neuronal tumor,and it thought to be originated from glial neuroprecursor cells or nerve stem cells.The incidence was low and had a good prognosis.

关 键 词：脑肿瘤 乳头胶质神经元肿瘤 PGNT 病理特点 

分 类 号：R739[医药卫生—肿瘤]