34例垂体腺瘤卒中患者资料的回顾性分析  

Retrospective analysis of the clinical data of 34 patients with pituitary adenoma stroke

作　　者：杜莹磊 姜之全[1] DU Ying-lei(Department of neurosurgery,the first affiliated hospital of Bengbu medical college,Bengbu,Anhui,233000,China)

机构地区：[1]蚌埠医学院第一附属医院神经外科,安徽蚌埠233000

出　　处：《齐齐哈尔医学院学报》2020年第3期290-292,共3页Journal of Qiqihar Medical University

基　　金：安徽省教育厅自然科学项目基金(KJ2018A0995)。

摘　　要：目的通过回顾性分析本院垂体卒中患者临床资料,结合国内外文献,讨论垂体卒中患者是否存在人口统计学差异及其主要的首发症状和激素检查中是否存在风险因素。方法回顾分析2014年1月-2019年1月收住蚌埠医学院第一附属医院神经外科的34例病理证实的垂体腺瘤卒中患者的临床资料,以及同期的263例垂体腺瘤患者临床资料。结果垂体腺瘤卒中男23例,女11例,与同期垂体腺瘤患者男125例,女138例相比,性别差异显著(P<0.05)。男性患者睾酮水平与垂体腺瘤卒中呈中等程度负相关且有统计学意义(P<0.05)。垂体卒中患者中,最常见的临床表现为霹雳性头痛(73.52%),其次为视力视野异常(58.82%),5例患者出现意识淡漠和昏迷表现(14.71%)。垂体腺瘤患者主要以轻微头痛头晕症状(71.86%)和或视力异常(60.47%)入院,5例患者出现意识淡漠,无昏迷患者。结论垂体卒中患者男性比例更高,有显著的性别差异,且血清睾酮水平低下是男性垂体卒中的风险因素。相较于垂体腺瘤患者,垂体卒中患者头痛更加剧烈,且有神志精神方面的改变。磁共振检查有利于卒中患者的检出。Objective To discuss whether there are demographic differences in pituitary apoplexy patients and whether there are risk factors in the main first symptoms and hormone tests,through retrospective analysis of clinical data of pituitary apoplexy patients in our hospital and combining with domestic and foreign literatures.Methods The clinical data of 34 patients with pathologically confirmed pituitary adenoma apoplexy admitted to the neurosurgery department of the first affiliated hospital of Bengbu medical college from January 2014 to January 2019 and 263 patients with pituitary adenoma during the same period were retrospectively analyzed.Results There were 23 males and 11 females with pituitary adenoma apoplexy.Compared with 125 males and 138 females in the same period,the difference of gender was statistically significant(P<0.05).Testosterone level in male patients was negatively correlated with pituitary adenoma stroke to a moderate extent and had statistical significance(P<0.05).Among pituitary apoplexy patients,the most common clinical manifestation was thunderbolt headache(73.52%),followed by abnormal visual field(58.82%),and 5 patients presented unconsciousness and coma(14.71%).Pituitary adenoma patients were mainly admitted due to mild headache and dizziness(71.86%)and/or abnormal vision(60.47%),none coma occurred.Conclusions The proportion of male patients with pituitary apoplexy is higher,with significant gender differences,and the low level of serum testosterone is the risk factor of pituitary apoplexy in male patients.Compared with patients with pituitary adenoma,patients with pituitary apoplexy have more severe headache,and they have mental and spiritual changes.Magnetic resonance examination is beneficial to the detection of stroke patients.

关 键 词：垂体腺瘤 卒中 睾酮 危险因素 

分 类 号：R736[医药卫生—肿瘤]