肥大细胞在口腔黏膜良性淋巴组织增生病中的表达及与临床病理的关系  

The expression of mast cells in benign lymphoid tissue hyperplasia of oral mucosa and its relationship with clinicopathology

作　　者：张昊[1] 刘慧娟 李荷香[2] 宋鹏[2] 刘旭倩 侯亚丽[3] ZHANG Hao;LIU Huijuan;LI Hexiang;SONG Peng;LIU Xuqian;HOU Yali(Department of Oral and Maxillofacial Surgery,School and Hospital of Stomatology,Hebei Medical University&Hebei Key Laboratory of Stomatology,Shijiazhuang 050017,China;Department of Oral Pathology,School and Hospital of Stomatology,Hebei Medical University&Hebei Key Laboratory of Stomatology,Shijiazhuang 050017,China;Department of Periodontics and Oral Mucosa,Affiliated Stomatology Hospital,Southwest Medical University,Sichuan Province,Luzhou)

机构地区：[1]河北医科大学口腔医学院·口腔医院口腔颌面外科,石家庄050017 [2]河北医科大学口腔医学院·口腔病理科,石家庄050017 [3]河北医科大学口腔医学院·河北省口腔医学重点实验室 [4]西南医科大学附属口腔医院牙周黏膜科

出　　处：《实用口腔医学杂志》2020年第3期482-486,共5页Journal of Practical Stomatology

基　　金：河北省医学科学研究重点课题(编号:ZD20140328)。

摘　　要：目的:探讨肥大细胞(mast cell,MC)在口腔黏膜良性淋巴组织增生病(benign lymphoadenosis of oral mucosa,BLOM)中的表达及与临床病理关系。方法:甲苯胺蓝组织化学和免疫组化染色观察30例BLOM和15例正常黏膜MC数量、脱颗粒率,分析其与临床病理关系。结果:2种染色MC总数及甲苯胺蓝染色MC脱颗粒率较正常黏膜增高(P<0.05),与年龄、性别、部位、病程及炎症轻重程度和黏膜固有层淋巴滤泡的形成无明显相关性(P>0.05)。结论:MC总数和脱颗粒率在BLOM明显增高,提示MC增殖和脱颗粒在BLOM发生发展中发挥重要作用。Objective:To explore the relationship between mast cell(MC)and clinicopathology in benign lymphoid tissue hyperplasia of oral mucosa(BLOM).Methods:The distribution,quantity and degranulation rate of MC in 30 cases of BLOM and 15 cases of normal mucosa were observed by toluidine blue histochemical staining and tryptase-like antibody immunohistochemical staining.The correlation between MC and clinical pathology was analyzed.Results:The total number of MC and degranulation rate of MC in BLOM were higher than those in normal mucosa(P<0.05).There was no significant correlation of MC expression with age,sex,lesion location,course of disease,severity of inflammation and formation of lymphoid follicles in lamina propria of the pationts(P>0.05).Conclusion:MC proliferation and degranulation play an important role in the occurrence and development of BLOM.

关 键 词：黏膜良性淋巴组织增生病(BLOM) 口腔 肥大细胞(MC) 脱颗粒 

分 类 号：R781.5[医药卫生—口腔医学]