脑内淋巴引流和Aβ清除机制对阿尔茨海默病防治的研究进展  

Enlightenment of brain lymphatic drainage and Aβclearance mechanism on the prevention and treatment of Alzheimer's disease

作　　者：周雪莹 徐武华[2] ZHOU Xueying;XU Wuhua(Graduate School Medical College of Jinan University,Guangzhou 510220,China;Guangzhou Red-Cross Hospital Affiliated with Medical College of Jinan University/The Institute of Clinical Pathological Nutrition of Guangzhou Red-Cross Hospital,Guangzhou 510220,China)

机构地区：[1]暨南大学医学院研究生院,广东广州510220 [2]暨南大学医学院附属广州市红十字会医院,广州市红十字会医院临床病态营养研究所,广东广州510220

出　　处：《中国实用神经疾病杂志》2020年第9期822-825,共4页Chinese Journal of Practical Nervous Diseases

基　　金：广州市科技计划项目(编号:201604020100)。

摘　　要：以减少Aβ沉积为标靶的Aβ疫苗的研究失败使人们开始反思阿尔茨海默病主流病理机制—Aβ级联反应学说的局限性,而新近证实的脑淋巴引流系统在打破了诸多传统观念的同时,也为诠释AD的病理机制提供了新的思路。本文拟全面介绍脑淋巴引流途径以及它们在Aβ清除机制中的作用,进而展望其在未来AD防治中的应用前景。The failure of research on the vaccines against Aβtargeting at reducing its deposition has made people reflect the limitations of amyloid cascade hypothesis,which is the mainstream pathological mechanism of Alzheimer's disease.While the newly confirmed brain lymphatic drainage system breaks many traditional concepts,it also provides a new way to interpret the pathological mechanism of AD.In this paper,we will comprehensively introduce the brain lymphatic drainage and their role in the mechanism of Aβclearance,and then look forward to their applications in the prevention and treatment of AD in the future.

关 键 词：阿尔茨海默病 脑淋巴引流 Β-淀粉样蛋白 胶质-淋巴 脑膜淋巴管 

分 类 号：R749.16[医药卫生—神经病学与精神病学]