Activating proper inflammation for wound-healing acceleration via mesoporous silica nanoparticle tissue adhesive  

作　　者：Zhao Pan Kai-Run Zhang Huai-Ling Gao Yong Zhou Bei-Bei Yan Chi Yang Zhi-Yuan Zhang Liang Dong Si-Ming Chen Rui Xu Duo-Hong Zou Shu-Hong Yu 

机构地区：[1]Division of Nanomaterials&Chemistry,Hefei National Laboratory for Physical Sciences at the Microscale,CAS Center for Excellence in Nanoscience,Hefei Science Center of CAS,Collaborative Innovation Center of Suzhou Nano Science and Techology Department of Chemistry,University of Science and Technology of China,Hefei 230026,China [2]Department of Oral Surgery,Ninth People's Hospital,Shanghai Jjiao Tong University School of Medicine,Shanghai Key Laboratory of Stomatology,National Clinical Research Center of Stomatology,Shanghai 200011,China [3]Key Laboratory of Oral Diseases Research ofAnhui Province,Stomatologic Hospital&Collge,Anhui Medical University Heifei 230032,China

出　　处：《Nano Research》2020年第2期373-379,共7页纳米研究（英文版）

基　　金：This work was supported by the National Natural Science Foundation of China(Nos.51732011,21431006,21761132008,51471157,21401183,and 21771168);the Foundation for Innovative Research Groups of the National Natural Science Foundation of China(No.21521001);Key Research Program of Frontier Sciences,CAS(No.QYZDJ-SSW-SLH036);the National Basic Research Program of China(No.2014CB931800);the Users with Excellence and Scientific Research Grant of Hefei Science Center of CAS(No.2015HSC-UE007);the Youth Innovation Promotion Association of CAS(No.2014298).

摘　　要：Efficient initiation and resolution of inflammation are crucial for wound repair.However,with using tissue adhesives for wound repair,patients occasionally suffered from delayed healing process because slow elimination of those exogenous adhesives generally leads to chronic inflammation.As the demand for minimal invasive therapy continues to rise,desire for adhesive materials that can effectively reconnect surgical gaps and promote wound regeneration becomes increasingly urgent.Herein,by exploiting the inherent porous structure and performance of adhesion to tissue of mesoporous silica nanoparticles(MSNs),we demonstrate a tissue adhesive that can elicit acute inflammatory response and get eliminated after tissue reformation.With formation of nanocomposites in wound gaps,the injured tissues can get reconnected conveniently.The resultant accelerated healing process verifty that the strategy of exploiting unique properties of nanomaterials can effectively promote inflammation resolution and wound repair.This design strategy will inspire more innovative tissue adhesives for clinical applications.

关 键 词：mesoporous nanoparticle tissue adhesive wound repair INFLAMMATION accelerated healing 

分 类 号：TB383[一般工业技术—材料科学与工程]