扎冲十三味丸联合长春西汀治疗脑卒中后遗症临床研究  

Zhachong Shisanwei Pills Combined with Vinpocetine in Treatment of Sequela of Stroke

作　　者：王颖[1] 邓雪芹 WANG Yingi;DENG Xueqin(Department of Rehabilitation Medicine,The Affiliated Hospital of Chengdu University,Chengdu 610106,Sichuan,China;Department of Rehabilitation Medicine,Peopled Hospital,Dazhou 635100,Sichuan,China)

机构地区：[1]成都大学附属医院康复医学科,四川成都610106 [2]大竹县人民医院康复医学科,四川达州635100

出　　处：《中华中医药学刊》2020年第4期248-251,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：四川省科技厅科技支撑计划(2016SZ0034)。

摘　　要：目的观察扎冲十三味丸联合长春西汀治疗脑卒中后遗症的临床治疗效果。方法选取医院自2015年5月-2018年5月收治的96例脑卒中后遗症患者作为研究对象,将其分为观察组和对照组,每组48例。对照组患者均给予脑卒中后遗症常规治疗,包括给予系统性康复训练、任务导向性训练及营养支持等,同时给予长春西汀片,观察组患者在对照组的治疗基础上另给予扎冲十三味丸,两组患者均连续治疗1个月。治疗后,对两组患者的疗效进行评价。治疗前后,分别评价两组患者生活质量评分,主要评价项目包括物质生活、社会功能、心理健康、躯体健康及机体功能。治疗前后,分别检测两组患者血液流变学指标,主要包括血小板黏附率、全血高切黏度、纤维蛋白原、红细胞压积及血浆黏度。治疗前后,分别观察两组患者运动功能指标,主要包括Rivemead运动指数(RMI指数)、Berg平衡指数(BBS指数)、Meyer上肢运功功能指数(S-FMMFA上肢指数)及Meyer下肢运功功能指数(S-FMMFA下肢指数)。治疗前后,分别观察两组患者心理状态指标,主要包括焦虑自评量表(SAS评分)、汉密尔顿抑郁量表(HAMD评分)及精神状态量表(MMSE评分)。结果治疗后,观察组总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,观察组物质生活、社会功能、心理健康、躯体健康及思维功能评分均高于对照组,差异有统计学意义(P<0.05)。治疗后,观察组血小板黏附率、全血高切黏度、纤维蛋白原、红细胞压积及血浆黏度改善程度均优于对照组,差异有统计学意义(P<0.05)。治疗后,观察组RMI指数、BBS指数、S-FMMFA上肢指数及S-FMMFA下肢指数改善程度均优于对照组,差异有统计学意义(P<0.05),而SAS评分、HAMD评分及MMSE评分改善程度亦均优于对照组,差异有统计学意义(P<0.05)。结论扎冲十三味丸联合长春西汀治疗脑卒中后遗症疗效较好,值得�Objective To investigate the effects of Zhachong Shisanwei Pills combined with vinpocetine in the treatment of sequela of stroke.Methods Patients(96 cases) from May 2015 to May 2018 with sequela of stroke in hospital were randomly divided into the control group(48 cases) and treatment groups(48 cases).The control group received routine treatment, including systematic rehabilitation training, task-oriented training and nutritional support, while patients in the treatment group were administered with Zhachong Shisanwei Pills on the basis of the control group, lasting for 1 month. After treatment, the clinical effects were evaluated. Before and after treatment, life quality scores of patients in the two groups were evaluated, evaluation items mainly included material life, social function, mental health, physical health and body function. Before and after treatment, hemorheology indexes of the two groups were tested, including platelet adhesion rate, whole blood high shear viscosity, fibrinogen, hematocrit and plasma viscosity. Before and after treatment, the indexes of motor function in the two groups were observed, including rivemead movement index(RMI index), berg equilibrium index(BBS index), meyer upper limb function index(S-FMMFA upper limb index) and meyer lower limb function index(S-FMMFA lower limb index). Before and after treatment, the psychological state indicators of the two groups were observed, mainly including self-rating anxiety scale(SAS score), Hamilton depression scale(HAMD score) and mental state scale(MMSE score).Results After treatment, the effective rate in treatment group was significantly higher than that of the control group(P<0.05). After treatment, scores of physical life, social function, mental health, physical health and thinking function in the observation group were significantly higher than those in the control group(P<0.05). After treatment, the improvement of platelet adhesion rate, whole blood high viscosity, fibrinogen, hematocrit and plasma viscosity in the observation group w

关 键 词：扎冲十三味丸 长春西汀 脑卒中后遗症 临床研究 

分 类 号：R743[医药卫生—神经病学与精神病学]