高血压患者首发脑出血事件的高危因素分析  

Analysis of high risk factors of first cerebral hemorrhage in hypertensive patients

作　　者：王飞[1] 黄婷婷[2] 刘亚辉[3] 周舟[2] WANG Fei;HUANG Ting-ting;LIU Ya-hui;ZHOU Zhou(Department of Neurosurgery,Zhengzhou the Second People's Hospital,Zhengzhou 450004,China;不详)

机构地区：[1]郑州市第二人民医院神经外科,郑州450004 [2]河南中医药大学第一附属医院放射科,郑州450000 [3]郑州市第二人民医院放射科,郑州450004

出　　处：《医药论坛杂志》2020年第3期19-21,26,共4页Journal of Medical Forum

基　　金：河南省科技厅科技攻关项目(182102310294)。

摘　　要：目的分析高血压患者人群中首发脑出血事件的危险因素,为高血压脑出血(HICH)的防治提供循证支持。方法回顾性连续纳入2013年6月-2019年4月于郑州市第二人民医院诊断为高血压并行颅脑CT检查的患者,根据HICH的诊断,将其分为HICH阳性组及HICH阴性组。记录患者的一般临床资料、既往病史、体检、实验室检查等,采用单因素分析及二元Logistic回归模型探索HICH患者的高危风险因素。结果本研究最终共纳入456例患者,其中脑出血事件114例,发生率为25%,P>0.05。单因素分析显示性别、年龄、高血压患病时长、体重指数(BMI)、吸烟、酗酒、糖尿病、高胆固醇血症、高甘油三酯血症在两组间差异具有统计学意义(P<0.05);多因素Logisitc回归分析结果显示年龄、糖尿病、吸烟是高血压患者首发脑出血事件的独立危险因素(P<0.05)。结论年龄、吸烟、糖尿病均可增加高血压患者的发生脑出血的风险,应该针对以上危险因素进行早期预防。Objective To analyze the risk factors of the first time cerebral hemorrhage in hypertensive patients,provide evidence-based support for the prevention and treatment of hypertensive intracerebral hemorrhage(HICH).Methods From June 2013 to April 2019,patients who diagnosed as hypertension and underwent craniocerebral CT examination in Zhengzhou Second People’s Hospital were consecutive included.According to the diagnosis of HICH,the patients were divided into HICH positive group and HICH negative group.Baseline clinical data,past medical history,physical examination and laboratory examination were recorded.Multivariate logistic regression model was used to explore the high risk factors of HICH patients.Results A total of 456 patients were enrolled in this study,including 114 cases of cerebral hemorrhage,the incidence was 25P>0.050%.Univariate analysis showed that there were significant differences in gender,age,duration of hypertension,body mass index(BMI),smoking,drinking,diabetes,hypercholesterolemia and hypertriglyceridemia between the two groups(P>0.05);Multivariate logistic regression analysis showed that age,diabetes and smoking were independent risk factors for the first cerebral hemorrhage in patients with hypertension.Conclusion Age,smoking and diabetes mellitus can increase the risk of cerebral hemorrhage in patients with hypertension.Early prevention should be carried out for the above risk factors.

关 键 词：脑出血 高血压 高危因素 

分 类 号：R743.34[医药卫生—神经病学与精神病学]