脑卒中、轴突出芽与神经元微管  

Stroke,axonal sprouting and neuronal microtubules

作　　者：廖海康 金悦 姚华 李松林 LIAO Hai-kang;JIN Yue;YAO Hua;LI Song-lin(Institute of Neuroscience and Chemistry,Wenzhou University,Wenzhou 325035,China;Institute of Life Sciences,Wenzhou University,Wenzhou 325035,China;College of Life and Environmental Sciences,Wenzhou University,Wenzhou 325035,China)

机构地区：[1]温州大学神经科学与化学研究所,浙江温州325035 [2]温州大学生命科学研究院,浙江温州325035 [3]温州大学生命与环境科学学院,浙江温州325035

出　　处：《解剖科学进展》2020年第2期234-238,共5页Progress of Anatomical Sciences

基　　金：国家自然科学基金(81671229,81871032)。

摘　　要：轴突出芽是脑卒中功能恢复的一个重要过程,轴突再生与微管蛋白的修饰以及微管的动态稳定性密切相关。神经细胞的独特形态和结构由细胞骨架中的微管支持和装配,同时微管的特殊结构也为神经元的物质运输提供基础。微管蛋白结构上的多样化修饰,以及塌陷反应调节蛋白在神经细胞修复与轴突再生的过程中起重要作用;多种分子机制维持微管稳定性,由此决定轴突出芽的延伸方向。Axonal sprouting is a critical process of functional recovery from stroke.Axonal regeneration is closely linked to the modification of tubulin and the dynamic stability of tubules.The unique morphology and structural maintenance of neurons are supported and assembled by microtubules in the cytoskeleton while the special structure of microtubules provides the basis for transportation within neurons.In addition,the structural modification of tubulin plays an important role in neural repair and regeneration.Further,collapsin response mediator protein family also functions in maintaining the neuronal skeleton and promoting axonal regeneration.It has been noticed that diverse molecular mechanisms maintain the stability of microtubules,which determines the extension direction of axonal spouting.

关 键 词：酪氨酸 生长锥 动态稳定性 神经细胞 

分 类 号：R743[医药卫生—神经病学与精神病学]