葡萄胎恶变相关危险因素的分析研究  

The analysis and research of the hydatidiform mole factors associated with malignant transformation

作　　者：刘爽 陈永峰 胡金菊 薛荣 LIU Shuang;CHEN Yongfeng;HU Jinju;XUE Rong(Department of Gynecology,Maternity and Child Health Care Hospital of Xinjiang Uygur Autonomous Region,Xinjiang,Urumqi,830001,China;Department of Pathology,The Maternity and Child Health Care Hospital of Xinjiang Uygur Autonomous Region,Xinjiang,Urumqi,830001,China)

机构地区：[1]新疆维吾尔自治区(乌鲁木齐市)妇幼保健院妇科,乌鲁木齐830001 [2]新疆维吾尔自治区(乌鲁木齐市)妇幼保健院病理科,乌鲁木齐830001

出　　处：《新疆医学》2020年第1期6-9,共4页Xinjiang Medical Journal

基　　金：自治区卫生健康青年医学科技人才专项科研项目(项目编号:WJWY-201938)。

摘　　要：目的探讨葡萄胎恶变的临床相关危险因素,寻找能预测葡萄胎恶变的临床指标,从而提高诊治率。方法收集2014年1月~2018年1月因妊娠滋养细胞疾病住院的166例患者的临床病理资料,其中葡萄胎148例、侵蚀性葡萄胎18例,分析影响葡萄胎恶变的相关因素。结果葡萄胎恶变率为10.84%,葡萄胎的恶变与年龄,妊娠次数,既往葡萄胎史,葡萄胎清宫后血清hCG未呈对数下降有关(P<0.05),与流产史,二次清宫史,阴道出血,腹痛,卵巢黄素化囊肿,子宫大小,超声测量葡萄胎宫腔病变径线范围,滋养细胞增生程度,治疗前血清hCG值,术后病理无关(P>0.05)。结论年龄>40岁,妊娠次数,清宫术后血清hCG呈对数下降为葡萄胎恶变的相关危险因素,对葡萄胎恶变的预测有一定参考价值。Objective To explore the clinical risk factors of malignant transform of hydatidiform,and evaluate their predicting values.Methods The clinical data of 166 in-patients with trophoblast disease of pregnancy(GTD)in some hospital between January 2014 and January 2018 were retrospectively analyzed and summarized.There were 148 cases of hydatidiform mole and 18 cases of invasive mole,and the relevent factors affecting the hydatidiform mole malignant transformation were analyzed.Results The incidence of malignant transformation among hydatidiform mole was 10.84%.Malignant changes in hydatidiform moles were associated with age,gravidity,history of hydatidiform mole,hCG which hadn’t been linear decreased after evacuation(P<0.05),but it was not related with abortion,second surgical evacuation,vaginal bleeding,bellyache,theca lutein ovarian cyst,uterine size,radial line of uterine,trophoblastic hyperplasia,blood h CG levels before treatment and postoperative pathology.(P>0.05).Conclusions The ages,number of pregnancies,repeated hydatidiform mole,linear decreased hCG are the main risk factors that affect the malignant mole of hydatidiform mole.

关 键 词：葡萄胎 恶变 危险因素 

分 类 号：R737.33[医药卫生—肿瘤]