肝动脉介入化疗栓塞术联合还原型谷胱甘肽治疗在老年晚期肝癌患者中的应用  

Application of transcatheter arterial chemoembolization combined with reduced glutathione in elderly patients with advanced liver cancer

作　　者：高省伟 GAO Shengwei(The 16th People's Hospital of Zhengzhou City,Henan Province,Zhengzhou,Henan 452470,China)

机构地区：[1]河南省郑州市第十六人民医院,河南郑州452470

出　　处：《新疆医学》2020年第1期60-63,共4页Xinjiang Medical Journal

摘　　要：目的探讨肝动脉介入化疗栓塞术联合还原型谷胱甘肽治疗在老年晚期肝癌患者中的应用效果。方法选择2015年6月到2018年8月在河南省郑州市第十六人民医院收治的57例老年晚期肝癌患者为研究对象,将患者以随机数字表法分为A组(n=30)和B组(n=27),其中A组患者作为观察组采用肝动脉介入化疗栓塞术联合还原型谷胱甘肽作为治疗方案,B组患者采用常规药物化疗作为对照组,对比分析两组患者治疗后临床缓解率、肝功能指标和生活质量情况。结果治疗前两组患者各项肝功能指标比较差异无统计学意义(P>0.05);治疗后A组患者直接胆红素(6.5±1.8)μmol/L、总胆红素(21.5±2.1)μmol/L、谷草转氨酶(53.7±4.1)U/L、谷丙转氨酶(54.5±4.2)U/L,B组患者直接胆红素(15.4±2.2)μmol/L、总胆红素(40.9±3.5)μmol/L、谷草转氨酶(89.2±7.6)U/L、谷丙转氨酶(133.4±14.2)U/L,差异有统计学意义(P<0.05);治疗后A组患者CR 19例、PR 5例、SD 4例,CRR率93.3%,B组患者CR 5例、PR 7例、SD 8例,CRR率74.1%,差异有统计学意义(P<0.05);A组患者复发率7.5%,B组患者复发率25.0%,差异有统计学意义(P<0.05);A组患者复发率7.5%,B组患者复发率25.0%,差异有统计学意义(P<0.05);治疗后A组患者生活质量评分,分别为人际交往(49.14±5.22)分、情绪(48.15±6.02)分、精神状态(49.11±5.26)分、日常活动(48.35±7.43)分、睡眠(49.41±6.36)分和饮食状况(49.62±4.11)分,B组患者生活质量评分分别为人际交往(40.22±5.14)分、情绪(41.05±5.36)分、精神状态(40.16±4.15)分、日常活动(40.78±7.74)分、睡眠(41.15±6.45)分和饮食状况(40.02±5.27)分,差异有统计学意义(P<0.05);A组患者治疗后恶心呕吐3例、骨髓抑制5例、肝功能障碍0例,总发生率26.7%,B组患者治疗后恶心呕吐4例、骨髓抑制7例、肝功能障碍2例,总发生率48.1%,差异无统计学意义(P>0.05)。结论老年晚期肝癌患者应用肝动脉介入化疗栓塞术联合�Objective To investigate the effect of transcatheter arterial chemoembolization combined with reduced glutathione in elderly patients with advanced liver cancer.Methods 57 elderly patients with advanced liver cancer admitted to the 16 th People’s Hospital of Zhengzhou City,Henan Province were selected as subjects from June 2015 to August 2018.The patients were randomly divided into the Group A(n=30)and the Group B(n=27).The group A as the observation group,hepatic arterial chemoembolization combined with reduced glutathione was used as a treatment regimen.The Group B patients were treated with conventional drug chemotherapy as the control group.Post-clinical remission rate,liver function indicators and quality of life were compared.Results There were no significant differences in liver function indexes between these two groups before treatment(P>0.05).After treatment,patients in the Group A were directly bilirubin(6.5±1.8)μmol/L and total bilirubin(21.5±2.1)μmol/L,aspartate aminotransferase(53.7±4.1)U/L,alanine aminotransferase(54.5±4.2)U/L,the Group B patients with direct bilirubin(15.4±2.2)μmol/L,total bilirubin(40.9±3.5)μmol/L,aspartate aminotransferase(89.2±7.6)U/L,alanine aminotransferase(133.4±14.2)U/L,the difference was statistically significant(P<0.05).The recurrence rate of the Group A was 7.5%,and that of the Group B was 25.0%,the difference was statistically significant(P<0.05);the recurrence rate of the Group A was 7.5%,and that of the Group B was 25.0%,the difference was statistically significant(P<0.05);after treatment,the quality of life scores of the Group A were interpersonal communication(49.14±5.22),emotion(48.15±6.02),mental state(49.11±5.26)The scores of daily activity(48.35±7.43),sleep(49.41±6.36)and dietary status(49.62±4.11)in the Group B were interpersonal communication(40.22±5.14),emotion(41.05±5.36),mental status(40.16±4.15),daily activity(40.78±7.74),sleep(41.15±6.45)and dietary status(40.02±5.27),respectively.The difference was statistically significant(P<0.0

关 键 词：晚期肝癌 肝动脉介入栓塞术 还原型谷胱甘肽 临床缓解率 

分 类 号：R[医药卫生]