原发性睾丸弥漫大B细胞淋巴瘤长期临床疗效分析  

Long term clinical analysis of primary testicular diffuse large B cell lymphoma

作　　者：程宗三[1] 张小马 张贤生[2] 梁朝朝[2] Cheng Zongsan;Zhang Xiaoma;Zhang Xiansheng;Liang Chaozhao(department of urology,the forth affiliated hospital of anhui medical universily,hefei,anhui province 230011;department of urology,the first affiliated hospital of anhui medical university,hefei,anhui province 230022)

机构地区：[1]安徽医科大学第四附属医院泌尿外科,安徽合肥230011 [2]安徽医科大学第一附属医院泌尿外科,安徽合肥230022

出　　处：《中国男科学杂志》2020年第2期62-65,共4页Chinese Journal of Andrology

摘　　要：目的探讨原发性睾丸弥漫大B细胞淋巴瘤的临床特点、治疗及预后。方法回顾性分析安徽医科大学第四附属医院2010年12月至2017年12月10例经病理检查证实的10例原发性睾丸弥漫大B细胞淋巴瘤的临床资料,并结合相关文献对其临床特点、疗效进行分析和讨论。结果 10例患者病理均明确为睾丸弥漫性大B细胞淋巴瘤,其中IE期6例、IIE期2例,III期2例;所有患者行睾丸根治性切除术,术后均予以化疗,预防性放疗1例。术后平均随访时间24-109个月,随访中患者复发4例(其中死亡2例)、另治愈6例。结论原发性睾丸弥漫性大B细胞淋巴瘤临床少见,预后差,复发率及死亡率高,术后应积极予以R-CHOP方案化疗联合放疗及鞘内注射治疗预防复发,并密切随访早期发现转移灶,对于复发难治性患者可尝试行二线化疗方案、造血干细胞移植及新药治疗,延长患者生命。Objective To explore the clinical characteristics, treatment and prognosis of primary diffuse large B cell lymphoma of testis. Methods Clinical data of 10 patients with primary testicular diffuse large B cell lymphoma, who confirmed by pathological examination from December 2010 to December 2017 in the Fourth Affiliated Hospital of Anhui Medical University, were analyzed retrospectively, and the clinical characteristics and efficacy were analyzed and discussed in combination with relevant literature. Results All the patients were diagnosed as diffuse large B cell lymphoma of testis including 6 in IE stage, 2 in IIE stage and 2 in III stage. All patients underwent radical orchiectomy, subsequently received chemotherapy and preventive radiotherapy. The average follow-up time was 24-109 months. During the follow-up, 4 patients recurred(2 died) and 6 patients were cured. Conclusion Primary diffuse large B-cell lymphoma of testis is rare in clinic,with poor prognosis, high recurrence rate and mortality. After operation, R-CHOP chemotherapy combined with radiotherapy and intrathecal injection should be actively used to prevent recurrence. Early metastasis should be found during close follow-up. For patients with relapsed refractory, second-line chemotherapy, hematopoietic stem cell transplantation and new drug treatment can be tried to prolong the life of patients.

关 键 词：淋巴瘤 大B细胞 弥漫性 睾丸 临床疗效 随访 

分 类 号：R733.41[医药卫生—肿瘤]