FoxO3在食管鳞状细胞癌中的表达及临床意义  

Expression and clinical significance of FoxO3 in esophageal squamous cell carcinoma

作　　者：高丽花[1] 彭雯君 郝清亚[2] 刘军[1] 赵喜 GAO Lihua;PENG Wenjun;HAO Qingya;LIU Jun;ZHAO Xi(Affiliated Hospital,Nantong University,Nantong 226001,China;Nantong First People’s Hospital,Nantong 226001,China;College of Medicine,Nantong University,Nantong 226001,China)

机构地区：[1]南通大学附属医院,江苏南通226001 [2]南通市第一人民医院,江苏南通226001 [3]南通大学医学院,江苏南通226001

出　　处：《扬州大学学报（农业与生命科学版）》2020年第2期83-86,共4页Journal of Yangzhou University：Agricultural and Life Science Edition

基　　金：国家自然科学基金青年基金项目(81401796);南通市科技项目(MSZ18093)。

摘　　要：采用蛋白免疫印迹法、免疫组织化学法检测食管鳞状细胞癌及癌旁组织中FoxO3的表达水平,探讨其表达与临床病理学特征之间的关系以及对食管鳞癌患者生存预后的影响。结果表明:与癌旁组织相比, FoxO3定位在细胞核,在癌组织中表达降低,其表达与患者的T分期、临床分期、淋巴结转移状况呈负相关。Kaplan-Meier生存曲线分析提示, FoxO3高表达组患者的中位生存期比低表达患者延长15.1个月。COX模型分析表明, FoxO3表达有望成为食管鳞状细胞癌患者判断预后的独立因素。这一研究提示FoxO3表达下调可能影响食管鳞状细胞癌的发生发展,可作为判断食管鳞癌预后的生物学指标。To explore the relationship between the expression of FoxO3 and clinicopathological characteristics and the survival prognosis of patients with esophageal squamous cell carcinoma, Western blotting and immunohistochemical methods were used to detect the expression of FoxO3 in esophageal squamous cell carcinoma and adjacent tissues. The results show that compared to adjacent tissues, FoxO3 expression was mainly localized in the nucleus, and lower expressed in esophageal squamous cell carcinoma(ESCC) tissues. The expression of FoxO3 was negatively correlated with T stage, clinical stage, and lymph node metastasis. Kaplan-Meier survival analysis showed that the median survival time in the FoxO3 high expression group was 15.1 months longer than that of patients with low expression. Multivariate analysis of COX model, FoxO3 expression could be used as an independent factor for predicting the prognosis of patients with ESCC. Down-regulation of FoxO3 expression may be associated with the development of ESCC, it could be used as a biological indicator to judge the prognosis of ESCC.

关 键 词：食管鳞状细胞癌 FoxO3 免疫印迹法 免疫组织化学法 生存期 

分 类 号：R735.1[医药卫生—肿瘤]