神经内镜经鼻入路治疗侵袭性垂体腺瘤切除程度的危险因素分析  

Analysis of the risk factors for resection degree of invasive pituitary adenomas treated with endoscopic endonasal transsphenoidal approach

作　　者：刘乾坤[1] 李雪元 朱旭强[1] 吴力新[1] 甄英伟 罗文正[1] 闫东明[1] LIU Qiankun;LI Xueyuan;ZHU Xuqiang;WU Lixin;ZHEN Yingwei;LUO Wenzheng;YAN Dongming(The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学第一附属医院,河南郑州450052

出　　处：《中国实用神经疾病杂志》2020年第8期687-692,共6页Chinese Journal of Practical Nervous Diseases

基　　金：河南省医学科技攻关项目(编号:2018020043)。

摘　　要：目的探讨神经内镜经鼻入路治疗侵袭性垂体腺瘤切除程度的危险因素。方法收集2016-09—2019-06郑州大学第一附属医院神经外科治疗的侵袭性垂体腺瘤患者,回顾分析不同患者性别与年龄、肿瘤的Knosp分级、单侧或双侧海绵窦侵袭、大小与位置(鞍上或蝶窦)、质地、切除程度。结果单因素分析显示,肿瘤的Knosp分级与单双侧侵袭、体积大小与位置、肿瘤质地是影响切除程度的危险因素。多因素Logistic回归分析显示,Knosp分级、肿瘤大小与肿瘤质地为影响切除程度的独立危险因素。结论术前分析肿瘤Knosp分级与肿瘤大小,术中评估肿瘤质地,熟练操作与应用技巧,有助于提高切除程度。Objective To explore the risk factors of resection degree of invasive pituitary adenoma treated with endoscopic endonasal transsphenoidal approach.Methods Patients with invasive pituitary adenoma treated with neurosurgery in the First Affiliated Hospital of Zhengzhou University from September 2016 to June 2019 were retrospectively analyzed by gender and age,Knosp classification of tumor,unilateral or bilateral cavernous sinus invasion,size and position(upper saddle or sphenoid sinus),texture,degree of resection.Results Univariate analysis showed that Knosp grade,single or bilateral invasion,size,location and texture were risk factors influencing the degree of resection.Multivariate Logistic regression analysis showed that Knosp grade,tumor size and tumor texture were independent risk factors for the degree of resection.Conclusion Preoperative analysis of tumor Knosp grading and tumor size,intraoperative evaluation of tumor texture,experienced operation and applied skills can help improve the degree of resection.

关 键 词：神经内镜 侵袭性垂体腺瘤 切除程度 危险因素 辅助技术 

分 类 号：R739.6[医药卫生—肿瘤]