卡前列素氨丁三醇联合米非司酮治疗子宫肌瘤的疗效及不良反应发生率的影响分析  

Effects of Carprost, Tromethamine and Mifepristone on the Treatment of Uterine Fibroids and Incidence of Adverse Reactions

作　　者：杨春凤 YANG Chun-feng(Department of Pharmacy,Jinzhou Maternity and Infant Hospital,Jjinzhou 121000,China)

机构地区：[1]辽宁省锦州市妇婴医院药剂科,辽宁锦州121000

出　　处：《中国医药指南》2020年第16期116-117,共2页Guide of China Medicine

摘　　要：目的研究联合采用卡前列素氨丁三醇和米非司酮对子宫肌瘤治疗的效果,以方便为临床治疗工作提供科学的治疗依据。方法选择2017年3月至2018年7月我院所收治的子宫肌瘤患者78例作为研究对象,按照随机方法分为常规治疗组和联合治疗组,每组患者平均为39例,常规治疗组采用米非司酮口服治疗,联合治疗组在常规治疗组基础之上联合采用卡前列素氨丁三醇,比较两组患者治疗效果。结果常规治疗组的治疗总有效率为76.92%(30/39),联合治疗组的治疗总有效率为94.87%(37/39),联合治疗组明显高于常规治疗组,P<0.05,差异具有统计学意义;常规治疗组的不良反应发生率为17.95%(7/39),联合治疗组为20.51%(8/39),联合治疗组和常规治疗组之间无明显的差异性,P>0.05,差异具有统计学意义;治疗以后两组患者均有所改善,常规治疗组为(26.81±5.45)mm3,(152.4±15.41)mm3,联合治疗组为(20.12±4.12)mm3,(100.21±12.05)mm3,联合治疗组的改善情况明显优于常规治疗组,P<0.05,差异具有统计学意义。结论对子宫肌瘤在治疗时采用卡前列素氨丁三醇联合米非司酮进行治疗可以有效提升治疗效果,降低不良反应发生率,改善患者的子宫大小和子宫肌瘤大小,值得推广。Objective To study the effect of combination of carprost,aminobutanol and mifepristone on the treatment of uterine fibroids,so as to provide a scientific basis for clinical treatment.Methods Choice in March 2017 to July 2018 I the records of 78 patients with uterine fibroids institutes as the research object,according to the stochastic method is divided into regular treatment group and combination group,each group of patients with an average of 39 cases,conventional treatment group was treated with oral mifepristone and combined treatment group on the basis of routine treatment group joint using card other tromethamine,comparing two groups of patients with therapeutic effect.Results The total effective rate was 76.92%(30/39)in the conventional treatment group,and 94.87%(37/39)in the combined treatment group.The combined treatment group was significantly higher than the conventional treatment group,P<0.05,and the difference was statistically significant.The incidence of adverse reactions was 17.95%(7/39)in the conventional treatment group and 20.51%(8/39)in the combined treatment group.There was no significant difference between the combined treatment group and the conventional treatment group(P>0.05),and the difference was statistically significant.After treatment,both groups of patients showed improvement,with the improvement in the conventional treatment group(26.81±5.45)mm3,(152.4±15.41)mm3,and the combined treatment group(20.12±4.12)mm3,(100.21±12.05)mm3.The improvement in the combined treatment group was significantly better than that in the conventional treatment group,P<0.05,and the difference was statistically significant.Conclusion In the treatment of uterine fibroids,the combination of carprost,tromethamine and mifepristone can effectively improve the treatment effect,reduce the incidence of adverse reactions,and improve the size of the patient’s uterus and the size of uterine fibroids,which is worthy of promotion.

关 键 词：卡前列素氨丁三醇 米非司酮 子宫肌瘤 

分 类 号：R737.33[医药卫生—肿瘤]