ANXA1的肿瘤特性研究  

The Tumor Characteristics of ANXA1

作　　者：胡荣华 朱莉[1] 李诗 张莉[1] 胡琛琛 HU Ronghua;ZHU Li;LI Shi;ZHANG Li;HU Chenchen(Intensive Care Unit,Hubei Cancer Hospital,Wuhan 430079,China)

机构地区：[1]湖北省肿瘤医院重症医学科,武汉430079

出　　处：《中国比较医学杂志》2020年第5期127-131,共5页Chinese Journal of Comparative Medicine

基　　金：湖北省卫生计生联合基金项目(WJ2019H129)。

摘　　要：膜联蛋白A1(Annexin-A1,ANXA1)最初被认为是一种抗炎介质,现在越来越被证实与肿瘤有关,但其在肿瘤生长和转移中的作用尚不清楚,有些还存在矛盾。ANXA1的表达可能取决于肿瘤的分期或类型。ANXA1作为一把双刃剑,通常是抗增殖的,保护细胞免受DNA损伤,但同时它又可促进转移。因此应该根据肿瘤的类型、等级和分期,选择使用ANXA1作为癌症治疗或预后标志物的时间。ANXA1(Annexin-A1),originally known as an anti-inflammatory mediator,has been implicated in cancer.However,its functions in cancer growth and metastasis are unclear and conflicting.ANXA1 expression may be dependent on the stage or type of cancer.ANXA1 acts as a double-edged sword as it is generally antiproliferative,protecting cells against DNA damage,despite promoting metastasis.The use of ANXA1 as a therapeutic or prognostic marker for cancer must be carefully timed,and it must be employed carefully depending on the cancer type,grade,and stage.

关 键 词：膜联蛋白A1 肿瘤特性 

分 类 号：R-33[医药卫生]