IL-33及ST2在卵巢癌中的表达及临床意义  

EXPRESSION AND CLINICAL SIGNIFICANCE OF INTERLEUKIN-33 AND SUPPRESSION OF TUMORIGENICITY 2 IN OVARIAN CANCER

作　　者：赵丽荣[1] 宋晨 王翔宇[1] 张晶晶[1] 高萍[1] 戴红英[1] ZHAO Lirong;SONG Chen;WANG Xiangyu;ZHANG Jingjing;GAO Ping;DAI Hongying(Department of Gynecology, The Affiliated Hospital of Qingdao University, Qingdao 266003, China)

机构地区：[1]青岛大学附属医院妇科,山东青岛266003

出　　处：《精准医学杂志》2020年第2期165-168,共4页Journal of Precision Medicine

基　　金：山东省医药卫生科技发展计划(2016WS0279)。

摘　　要：目的探讨白细胞介素-33(IL-33)及致癌抑制因子2(ST2)蛋白在卵巢癌组织中的表达及其与患者临床病理特征的相关性。方法收集青岛大学附属医院妇科2010年1月—2013年12月手术切除卵巢患者的病理标本110例,其中卵巢癌60例,交界性肿瘤28例,良性肿瘤22例。选取20例正常卵巢组织作为正常对照组。采用免疫组织化学方法检测各种组织中IL-33及ST2蛋白的表达,分析其表达与卵巢癌临床病理参数的关系;并分析卵巢癌组织中IL-33与ST2蛋白表达的相关性。结果卵巢癌组织、交界性肿瘤组织中IL-33及ST2蛋白的阳性表达率明显高于正常卵巢组织(χ^2=7.406~19.710,P<0.05);临床Ⅲ~Ⅳ期、低分化卵巢癌组织中IL-33及ST2蛋白的阳性表达率明显高于Ⅰ~Ⅱ期及高分化卵巢癌组织(χ^2=3.972~5.319,P<0.05);卵巢癌组织中IL-33及ST2蛋白的表达与患者年龄、卵巢癌病理类型及淋巴结转移无关(P>0.05);IL-33及ST2蛋白在卵巢癌组织中的表达呈正相关(r=0.577,P<0.05)。结论IL-33及ST2蛋白在卵巢癌组织中高表达,且与卵巢癌的临床病理分期、分化程度有关,IL-33及ST2蛋白可能参与了卵巢癌的发生发展。Objective To investigate the protein expression of interleukin-33(IL-33)and suppression of tumorigenicity 2(ST2)in ovarian cancer and their association with clinicopathological features.Methods A total of 110 pathological specimens were collected from the patients who underwent ovariectomy in Department of Gynecology,The Affiliated Hospital of Qingdao University,from January 2010 to December 2013,among which there were 60 specimens of ovarian cancer,28 specimens of borderline tumor,and 22 specimens of benign tumor.A total of 20 specimens of normal ovarian tissue were selected as normal control group.Immunohistochemistry was used to measure the protein expression of IL-33 and ST2 in each type of tissue,and the association of the expression of IL-33 and ST2 with clinicopathological features of ovarian cancer was analyzed.The correlation between IL-33 and ST2 was also analyzed.Results The positive expression rates of IL-33 and ST2 in ovarian cancer tissue and borderline tumor tissue were significantly higher than those in normal ovarian tissue(χ^2=7.406-19.710,P<0.05).Poorly differentiated ovarian cancer tissue with a clinical stage ofⅢ-Ⅳhad significantly higher positive expression rates of IL-33 and ST2 than the well-differentiated ovarian cancer tissue with a clinical stage ofⅠ-Ⅱ(χ^2=3.972-5.319,P<0.05).In the ovarian cancer tissue,the protein expression of IL-33 and ST2 was not associated with the patient’s age,pathological type of ovarian cancer,and lymph node metastasis(P>0.05).The protein expression of IL-33 was positively correlated with that of ST2(r=0.577,P<0.05).Conclusion\IL-33 and ST2 proteins are highly expressed in ovarian cancer tissue and are associated with the clinicopathological stage and degree of differentiation of ovarian cancer,and they may be involved in the development and progression of ovarian cancer.

关 键 词：卵巢肿瘤 白细胞介素33 致癌抑制因子2 肿瘤分期 肿瘤分级 相关性分析 免疫组织化学 病理状态 体征和症状 

分 类 号：R737.31[医药卫生—肿瘤]