Pax转录激活结构域相关蛋白PTIP的研究进展  

Research Progress of Pax Transcriptional Activation Domain Related Protein

作　　者：王元琪 刘云章[1] 周建峰[1] 荣小至 WANG Yuan-qi;LIU Yun-zhang;ZHOU Jian-feng;RONG Xiao-zhi(School of Medicine and Pharmacy,Ocean University of China,Qingdao Shandong 266003,China)

机构地区：[1]中国海洋大学医药学院,山东青岛266003

出　　处：《医学食疗与健康》2020年第10期215-216,218,共3页Medical Diet and Health

基　　金：国家自然科学基金(31601863,31872189,30972238)。

摘　　要：PTIP蛋白(PAX Transcription activation domain Interacting Protein,PAXIP1)含有6个BRCT结构域和位于蛋白中间的polyQ区域。研究表明PTIP通过控制组蛋白甲基化来调节基因转录且在DNA损伤修复和维持基因组的稳定性中发挥着重要作用。本文对近年来关于PTIP的重要结构域以及其在生物体发育中的重要功能研究进展作一综述。PAX transcription activation domain interacting protein(PTIP),also known as PAXIP1,has six BRCT domains and a poly Q region.Previous studies have shown that PTIP regulates gene transcription by controlling histone methylation and plays important roles in repairing DNA damage and maintaining the genome stability.Here,we review the recent research progress on the domain of PTIP and its important functions in the development of organisms.

关 键 词：PTIP BRCT 53BP1 组蛋白甲基化 损伤修复 

分 类 号：R730.2[医药卫生—肿瘤]