c-Src在HR+乳腺癌休眠骨转移中作用机制的研究进展  

Research Progress of c-Src in the Mechanism of Dormant Bone Metastasis in HR+Breast Cancer

作　　者：夏龙杰 于滢华[1] 莫钦国[1] Xia Longjie;Yu Yinghua;Mo Qinguo(Guangxi Medical University Affiliated Tumor Hospital,Nanning 530021,China)

机构地区：[1]广西医科大学附属肿瘤医院,南宁530021

出　　处：《广西医科大学学报》2020年第5期967-971,共5页Journal of Guangxi Medical University

基　　金：广西自然科学基金项目(No.2017GXNSFAA198088)。

摘　　要：骨是HR+晚期乳腺癌的最常见转移部位。乳腺癌休眠骨转移是骨转移的潜伏阶段,一旦发生骨转移,临床分期由早期转为晚期,严重影响患者的生活质量和生存时间。将骨转移扼杀在休眠萌芽阶段对患者的生存至关重要。本综述重点探讨了乳腺癌休眠骨转移的分子机制及c-Src基因及通路在其中的作用,以期为寻找新的治疗靶点、发现新的特异性肿瘤标志物提供研究思路。Bone is the most common metastatic site of HR+advanced breast cancer.Dormant bone metastasis of breast cancer is the latent stage of bone metastasis.Once bone metastasis is observed,the clinical stage will change from early stage to late stage,which seriously affects the patients’life quality and survival time.Eliminating bone metastasis in the budding stage of dormancy is essential for the patients’survival.This review focuses on the molecular mechanism of dorment bone metastasis of breast cancer and the role of c-Src gene and pathway inthismolecular mechanism,in order to provide research methods for finding new therapeutic targets and finding new specific tumor markers.

关 键 词：乳腺癌 休眠骨转移 非受体酪氨酸蛋白激酶 丝裂原活化蛋白激酶 

分 类 号：R737.9[医药卫生—肿瘤]