直径小于1 cm孤立性肺结节的18F-FDG PET/CT诊断研究进展  

Progress in Diagnosis of Solitary Pulmonary Nodules with Diameter Less Than 1 cm by 18F-FDG PET/CT

作　　者：滕月 孙莹莹[1,2] 孙夕林[1,2] Avishek Swar[1,2] TENG Yue;SUN Ying-ying;SUN Xi-lin;Avishek Swar(TOF-PET/CT/MR Center,the Fourth Hospital of Harbin Medical University,Harbin,Heilongjiang,150028,China;Molecular Imaging Research Center(MIRC),Harbin Medical University,Harbin,Heilongjiang,150028,China)

机构地区：[1]哈尔滨医科大学附属第四医院TOF-PET/CT/MR中心,黑龙江哈尔滨150028 [2]哈尔滨医科大学分子影像研究中心,黑龙江哈尔滨150028

出　　处：《现代生物医学进展》2020年第6期1193-1196,共4页Progress in Modern Biomedicine

基　　金：国家重点基础研究发展计划项目(2015CB931800);国家自然科学基金项目(81471724,81627901)。

摘　　要：孤立性肺结节的鉴别诊断一直是胸部影像学的研究热点。早期且准确地鉴别肺内小结节的良恶性,对于患者治疗方案的确定以及随访情况的评估均具有重要的临床意义。18F-FDG PET/CT在鉴别诊断恶性肿瘤方面具有明显优于其他传统检查的高特异性和高敏感性,其公认的恶性肿瘤的诊断阈值是最大化标准摄取值(maximum standard uptake value,SUVmax)为2.5,然而部分临床数据显示一些直径小于1 cm的恶性肺结节的SUVmax数值小于2.5。因此在早期研究中,18F-FDG PET/CT在诊断直径较小的肺结节的其临床价值仍存在争议。为了尽量降低SUVmax的测量误差,提高18F-FDG PET/CT诊断的准确率,衍生出了许多SUVmax辅助诊断方法以及优化的重建算法、放射性显像剂的联合应用等手段。本文将对18F-FDG PET/CT鉴别诊断直径小于1 cm孤立性肺结节的研究进展进行综述。The differential diagnosis of solitary pulmonary nodules has been a hot topic in chest imaging. Early and accurate identification of the benign and malignant small pulmonary nodules has important clinical significance for the determination of the patient’s treatment plan and the evaluation of follow-up.18F-FDG PET/CT is recognized as a highly specific and highly sensitive method for the differential diagnosis of malignant tumors. Its recognized diagnostic threshold for malignant tumors is the SUVmax to 2.5. However,some clinical data indicate that SUVmax values for malignant pulmonary nodules that less than 1 cm in diameter are less than 2.5. Therefore, in early studies, the clinical value of 18F-FDG PET/CT in the diagnosis of small diameter pulmonary nodules remains controversial.In order to minimize the measurement error of SUVmax and improve the accuracy of 18F-FDG PET/CT diagnosis, many SUVmax auxiliary diagnostic methods, optimized reconstruction algorithms and combined application of radioactive imaging agents have been derived.This article will investigate the advances in the differential diagnosis of 18F-FDG PET/CT for solitary pulmonary nodules less than 1 cm in diameter.

关 键 词：小直径孤立性肺结节 18F-FDG PET/CT 研究进展 

分 类 号：R734.2[医药卫生—肿瘤] R445.1[医药卫生—临床医学]