托吡酯大剂量冲击疗法治疗小儿癫痫的临床效果及安全性  

Clinical efficacy and safety of topiramate high-dose shock therapy in the treatment of children with epilepsy

作　　者：陈振华[1] 夏毅如 吴乃许[1] Chen Zhenhua;Xia Yiru;Wu Naixu(Department of Pediatrics,Gaoming District People′s Hospital of Foshan,Foshan 528500,China)

机构地区：[1]佛山市高明区人民医院儿科,广东佛山528500

出　　处：《中国临床实用医学》2020年第2期45-47,共3页China Clinical Practical Medicine

摘　　要：目的:分析托吡酯大剂量冲击疗法治疗小儿癫痫的临床效果及安全性。方法:选取2015年5月至2019年5月佛山市高明区人民医院儿科收治的86例癫痫患儿,男47例,女39例,年龄(8.06±0.62)岁,年龄范围为4~12岁。按照随机数表法将患儿随机分为大剂量治疗组和小剂量治疗组,每组43例。大剂量治疗组患儿采用大剂量托吡酯冲击治疗,小剂量治疗组患儿采用小剂量托吡酯治疗,两组患儿均治疗12周,比较两组患儿临床治疗效果、言语智商(VIQ)、总智商(FIQ)评分及不良反应(感觉异常、注意力分散、恶心头晕)发生情况。结果:大剂量治疗组临床有效率[95.3%(41/43)]明显高于小剂量治疗组[69.8%(30/43)],差异有统计学意义(P<0.05)。治疗前两组患儿VIQ、FIQ评分比较,差异无统计学意义(P>0.05);治疗后大剂量治疗组VIQ[(108.26±6.85)分]、FIQ评分[(109.26±3.64)分]均高于小剂量治疗组[(96.85±1.62)分、(100.05±2.84)分],差异有统计学意义(P<0.05)。大剂量治疗组不良反应发生率与小剂量治疗组比较,差异无统计学意义(P>0.05)。结论:大剂量托吡酯冲击治疗小儿癫痫可有效减少癫痫发作次数,改善患儿认知功能,且不良反应较少,值得在临床上推广应用。Objective To analyze the clinical efficacy and safety of topiramate high-dose shock therapy in the treatment of children with epilepsy.Methods A total of 86 children with pediatric epilepsy who were admitted to the Pediatrics of Gaoming District People′s Hospital from May 2015 to May 2019 were selected,aged 4 to 12 years old,and the age range was(8.06±0.62)years old.The children were randomly divided into the high-dose treatment group and the low-dose treatment group,with 43 cases in each group.Patients in the high-dose treatment group were treated with high-dose topiramate shock,and patients in the low-dose treatment group were treated with low-dose topiramate shock.Both groups were treated for 12 weeks.Clinical treatment effect,verbal intelligence quotient(VIQ),full intelligence quotient(FIQ)score and adverse reactions(paresthesia,distraction,nausea and dizziness)were compared between the two groups.Results The clinical effectiveness of the high-dose treatment group[95.3%(41/43)]was significantly higher than that of the low-dose treatment group[69.8%(30/43)],and the difference was statistically significant(P<0.05).There was no significant difference in VIQ and FIQ scores between the two groups of children before treatment(P>0.05);both VIQ[(108.26±6.85)points]and FIQ scores[(109.26±3.64)points]of the high-dose treatment group after treatment was significantly higher than the low-dose treatment group[(96.85±1.62)points,(100.05±2.84)points],and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the high-dose treatment group and the low-dose treatment group(P>0.05).Conclusion High-dose topiramate shock treatment for pediatric epilepsy can effectively reduce the number of seizures,improve children′s cognitive function,and less adverse reactions,it is worthy of clinical application.

关 键 词：托吡酯 大剂量冲击 癫痫 言语智商 总智商 

分 类 号：R742[医药卫生—神经病学与精神病学]