湖南部分地区2877例前列腺癌患者临床流行病学特征及流行学趋势分析  

Clinical features and epidemiological trend of prostate cancer in the Changsha area of Hunan Province: Analysis of 2 877 cases

作　　者：高瑞松 周青[1] 张晓波[2] 曾普华 田雪飞[4] 龙衍 舒译 罗新筠 GAO Rui-song;ZHOU Qing;ZHANG Xiao-bo;ZENG Pu-hua;TIAN Xue-fei;LONG Yan;SHU Yi;LUO Xin-jun(Department of Andrology,The First Affiliated Hospital of Hunan University of Chinese Medicine,Changsha,Hunan 410007,China;Xiangya International Medical Center,Xiangya Hospital,Central South University,Changsha 41008,Hunan,China;Department of Oncology,The Affiliated Hospital of Hunan Research Institute of Chinese Medicine;School of Integrated Traditional Chinese and Western Medicine,Hunan University of Chinese Medicine,Changsha,Hunan 410208,China;Graduate School,Hunan University of Chinese Medicine,Changsha,Hunan 410208,China)

机构地区：[1]湖南中医药大学第一附属医院男科,湖南长沙410007 [2]中南大学湘雅医院国际医疗部外科国家老年临床研究中心(湘雅),湖南长沙410008 [3]湖南中医药研究院附属医院肿瘤科,湖南长沙410006 [4]湖南中医药大学中西医结合学院,湖南长沙410208 [5]湖南中医药大学研究生院,湖南长沙410208

出　　处：《中华男科学杂志》2020年第4期309-315,共7页National Journal of Andrology

基　　金：国家自然科学基金(81704093);湖南省教育厅科学研究项目(重点)(19A384);湖南中医药大学中西医结合一流学科开放基金(2019ZXYJH14);湖南省高层次卫生人才225工程培养项目资助(湘卫函2019196号)。

摘　　要：目的:分析湖南部分地区前列腺癌患者流行病学特征,为防控策略的制定提供参考。方法:收集2010年1月1日~2019年12月31日就诊中南大学湘雅医院、湖南中医药大学第一附属医院、湖南中医药研究院附属医院的2 877例前列腺癌患者年龄、病理类型和中医证型资料,分析探讨前列腺癌发病现状及流行趋势。结果:2010年291例,2011年315例,2012年213例,2013年220例,2014年159例,2015年226例,2016年199例,2017年180例,2018年577例,2019年497例。患病人群年龄资料显示:40岁以下罕见,65~79岁呈高发病率。年龄组变化趋势为:65~79岁年龄组发病比例逐年增加,10年间增加至63.9%;80岁及以上组发病上升更明显,10年间增长率达到97.9%。病理分型中主要为腺癌。腺癌1441例(50.1%),腺泡细胞腺癌例201例(7.00%);滤泡状腺癌37例(1.29%),前列腺导管癌27例(0.94%),病例未特指273例(9.49%),其他腺癌166例(5.77%)。其中157例患者进行了中医辨证分型,主要为肾虚证型,其中肾阴虚者40例(25.5%),肾阳虚69例(43.9%)。结论:2010~2019年湖南地区前列腺癌发病呈老龄化趋势,65~69岁为发病峰值,65~79老年男性为高危人群,需加强健康宣教和早诊早治工作,降低其发病率。Objective: To analyze the epidemiological characteristics of PCa in the Changsha area of Hunan Province and provide some reference for the formulation of the strategies for the prevention and control of the malignancy. Methods: We collected the data on the age, pathological type and TCM syndrome type of 2 877 PCa patients diagnosed and treated in Xiangya Hospital of Central South University, the First Affiliated Hospital of Hunan University of Chinese Medicine and the Affiliated Hospital of Hunan Research Institute of Chinese Medicine from January 1, 2010 to December 31, 2019. We analyzed the data obtained and the current prevalence and epidemiological trend of PCa. Results: Of the total number of cases of PCa diagnosed and treated, there were 291 in 2010, 315 in 2011, 213 in 2012, 220 in 2013, 159 in 2014, 226 in 2015, 199 in 2016, 180 in 2017, 577 in 2018 and 497 in 2019. The age-related incidence rate was the lowest in the <40-year-olds(1.77%) and the highest in the 65-to 79-year-olds(18.4%). The incidence rate was increased year by year in the 65-to 79-year-olds, elevated to 63.9% in the 10 years, and most significantly in the ≥80-year-olds, soaring to 97.9% in the 10 years. As for the pathological types, prostatic adenocarcinoma(PAC) accounted for 50.1%(n = 1 441), acinar cell PAC 7.0%(n = 201), follicular PAC 1.29%(n = 37), ductal PCa 0.94%(n = 27), non-specific PCa 9.49%(n = 273), and other PACs 5.77%(n = 166). TCM syndrome differentiation was performed for 157 cases, which revealed kidney-yin deficiency in 40 cases(25.5%) and kidney-yang deficiency in 69 cases(43.9%). Conclusion: The incidence of PCa from 2010 to 2019 showed an aging-related trend in the Changsha area of Hunan Province, the highest among 65-to 69-year-olds. Males aged 65-79 years are a high-risk population for PCa, which calls for strengthened health education, early diagnosis and early treatment.

关 键 词：前列腺癌 临床特征 湖南地区 流行趋势 

分 类 号：R737.25[医药卫生—肿瘤]