缺失牙数与非酒精性脂肪肝的相关研究  

Association between tooth missing and non-alcoholic fatty liver disease

作　　者：付凯钰 乔峰[2] 孟革[2] 张卿 刘莉[2] 宋崑 牛凯军[2,3] Fu Kaiyu;Qiao Feng;Meng Ge;Zhang Qing;Liu Li;Song Kun;Niu Kaijun(Graduate School of Tianjin Medical University,Tianjin 300070,China;Nutritional Epidemiology Institute and School of Public Health,Tianjin Medical University,Tianjin 300070,China;Health Management Centre,Tianjin Medical University General Hospital,Tianjin 300052,China)

机构地区：[1]天津医科大学研究生院,300070 [2]天津医科大学营养流行病学研究所,公共卫生学院,300070 [3]天津医科大学总医院健康管理中心,300052

出　　处：《中华流行病学杂志》2020年第5期716-721,共6页Chinese Journal of Epidemiology

基　　金：天津市科技支撑计划重点项目(11ZCGYSY05700,12ZCZDSY20400,13ZCZDSY20200,15YFYZSY00020)。

摘　　要：目的评价成年人群中缺失牙的数量和非酒精性脂肪肝(NAFLD)之间的关联。方法对26983名来源于天津营养流行病学队列(TCLSIH研究)的成年人进行横断面研究。根据缺失牙数(第三磨牙除外),分为0、1~、3~和≥6颗4组。NAFLD的诊断采用腹部超声检查和ALT测定,采用logistic回归分析成年人中缺失牙数与NAFLD之间的关系。结果NAFLD患病人数为7270人,至少有1颗牙缺失的人数为9667人。经调整混杂因素后,根据缺失牙数从少到多(0、1~、3~和≥6颗)各组中,人群NAFLD患病的OR值(95%CI)分别为:男性1.00、1.04(0.93~1.15)、1.08(0.93~1.26)和1.38(1.09~1.76)(趋势检验P=0.030);女性1.00、0.96(0.82~1.12)、1.11(0.91~1.35)和1.22(0.90~1.64)(趋势检验P=0.450)。结论男性缺失牙的数目≥6颗与NAFLD的高患病率相关,女性中无显著相关性。Objective To evaluate the association between the number of teeth missed and the prevalence of non-alcoholic fatty liver disease(NAFLD)in adults.Methods A cross-sectional study was carried out in 26983 adults from Tianjin Chronic Low-grade Systemic Inflammation and Health Cohort Study.The number of teeth missed(excluding third molars)was recorded and classified into four categories:0,1-,3-and≥6.NAFLD was diagnosed by at least two liver ultrasonography examinations.Adjusted multivariable logistic regression analysis was used to access the association between the number of missed teeth and NAFLD in adults.Results The overall prevalence of NAFLD was 7270 and the number of the subjects with at least one tooth missed was 9667.The multivariable-adjusted ORs(95%CI)of NAFLD across the categories of tooth missing(0,1-,3-and≥6)were as follows:1.00,1.04(0.93-1.15),1.08(0.93-1.26)and 1.38(1.09-1.76)(trend test P=0.030)in males;1.00,0.96(0.82-1.12),1.11(0.91-1.35)and 1.22(0.90-1.64)(trend test P=0.450)in females.Conclusion The number of missed teeth was positively associated with a higher prevalence rate of NAFLD in males with over 6 teeth missed,but not in females.

关 键 词：非酒精性脂肪肝 缺失牙 牙周炎 

分 类 号：R575[医药卫生—消化系统]