血清甲状腺激素水平检测在肺癌诊断及淋巴结转移监测中的价值  

The value of serum thyroid hormone level in lung cancer diagnosis and lymph node metastasis monitoring

作　　者：钟斌[1] 饶运帷 李林[2] Zhong Bin;Rao Yunwei;Li Lin(Department of Respiratory Medicine,the First Affiliated Hospital of Gannan Medical University,Ganzhou 341000,China;Department of Chest Oncology,Jiangxi Cancer Hospital,Nanchang 330029,China)

机构地区：[1]赣南医学院第一附属医院呼吸内科,赣州341000 [2]江西省肿瘤医院胸部肿瘤内科,南昌330029

出　　处：《国际呼吸杂志》2020年第10期731-736,共6页International Journal of Respiration

摘　　要：目的探讨血清甲状腺激素水平在肺癌诊断及淋巴结转移监测中的临床价值。方法选取赣南医学院第一附属医院呼吸内科及江西省肿瘤医院胸部肿瘤内科收治的肺癌患者共79例作为肺癌组,同时选取同期体检健康者共42例作为健康对照组,采用电化学发光法测定79例肺癌患者和42例健康者的血清甲状腺激素水平,包括游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、总三碘甲状腺原氨酸(TT3)、总甲状腺素(TT4)以及促甲状腺素。分析比较肺癌组与健康对照组、淋巴结转移肺癌患者与无淋巴结转移肺癌患者的血清FT3、FT4、TT3、TT4、促甲状腺素水平差异。采用Logistic回归分析筛选出对诊断肺癌及监测淋巴结转移有用的指标,并用受试者工作特征曲线评价各指标在肺癌诊断及淋巴结转移监测中的价值。结果肺癌组血清FT3、FT4、TT3、TT4水平均低于健康对照组,差异均有统计学意义(P值均<0.001)。Logistic回归分析显示,血清FT3、FT4与肺癌诊断相关(P值均<0.001),血清FT3、FT4及两者联合诊断肺癌的曲线下面积分别为0.911、0.887和0.945,差异均有统计学意义(P值均<0.001)。淋巴结转移肺癌患者血清FT3、TT3水平均低于无淋巴结转移肺癌患者,差异均有统计学意义(P值均<0.001)。Logistic回归分析显示,血清FT3、TT3水平与肺癌淋巴结转移相关(P值均<0.05),血清FT3、TT3及两者联合监测肺癌淋巴结转移的曲线下面积分别为0.796、0.733和0.855,差异均有统计学意义(P值均<0.001)。结论肺癌患者血清甲状腺激素水平发生改变,检测血清甲状腺激素水平可辅助肺癌诊断及淋巴结转移监测。Objective To investigate the clinical value of serum thyroid hormone level in diagnosis of lung cancer and monitoring of lymph node metastasis.Methods A total of 79 patients with lung cancer from Department of Respiratory Medicine of the First Affiliated Hospital of Gannan Medical University or Department of Chest Oncology of Jiangxi Cancer Hospital were selectet as the lung cancer group,and 42 healthy subjects in the same period were selected as the health control group.Serum thyroid hormone levels,including free triiodothyronine(FT3),free thyroxine(FT4),total triiodothyronine(TT3),total thyroxine(TT4)and thyroid stimulating hormone(TSH)were measured by electrochemiluminescence assay in 79 patients with lung cancer and 42 healthy subjects.Serum FT3,FT4,TT3,TT4 and TSH levels in different groups of subjects were compared.Logistic regression analysis was used to identify the useful indicators,and receiver operating characteristic curve(ROC)analysis was used to evaluate the clinical value of various indicators in diagnosis of lung cancer and monitoring of lymph node metastasis.Results Levels of serum FT3,FT4,TT3 and TT4 in lung cancer were significantly lower than those in healthy subjects(P<0.001);the Logistic regression analysis showed that serum FT3 and FT4 were correlated with lung cancer diagnosis(all P<0.001);ROC analysis showed that the area under curve of serum FT3,FT4 and their joint detection in lung cancer diagnosis were 0.911,0.887 and 0.945,respectively(all P<0.001).Levels of serum FT3 and TT3 were significantly lower in lung cancer with lymph node metastasis compared to those without lymph node metastasis(both P<0.001);the Logistic regression analysis showed that serum FT3 and TT3 were associated with lymph node metastasis in lung cancer(both P<0.05);ROC analysis showed that the area under curve of serum FT3,TT3 and their combined detection in lymph node metastasis monitoring were 0.796,0.733 and 0.855,respectively(all P<0.001).Conclusions Serum thyroid hormone levels have changed in lung cancer,and d

关 键 词：肺肿瘤 甲状腺激素 淋巴结 肿瘤转移 ROC曲线 

分 类 号：R734[医药卫生—肿瘤]