HBV cccDNA转录代谢调控机制及沉默清除策略  

Regulatory mechanisms of the transcription and metabolism of hepatitis B virus covalently closed circular DNA and strategies for silencing and elimination

作　　者：宰文静 陈捷亮[1] 袁正宏[1] ZAI Wenjing;CHEN Jieliang;YUAN Zhenghong(MOE & NHC Key Laboratory of Medical Molecular Virology, Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China)

机构地区：[1]复旦大学上海医学院,基础医学院病原生物学系,医学分子病毒学教育部/卫健委重点实验室,上海200032

出　　处：《临床肝胆病杂志》2020年第5期983-988,共6页Journal of Clinical Hepatology

基　　金：国家自然科学基金项目(81974304,91842309)。

摘　　要：已知HBV cccDNA在感染肝细胞的细胞核内以微染色体的形式持续稳定存在,难以被靶向调控和清除。围绕HBV cccDNA持续沉默或降解清除机制及策略的研究是当前慢性乙型肝炎“功能性治愈”目标下的重点。介绍了目前对cccDNA基本生物学特性、转录和代谢调控机制及相关宿主因子的认知,重点分析了cccDNA沉默清除的可能途径和靶向调控策略。It is known that hepatitis B virus(HBV)covalently closed circular DNA(cccDNA)persists in the nucleus of infected hepatocytes in the form of minichromosome and is difficult to target and eliminate.Studies on the mechanisms and strategies for persistent silencing or elimination of HBV cccDNA are the focus achieving for“functional cure”of chronic hepatitis B.This article introduces the current knowledge on the basic biological features of cccDNA,regulatory mechanisms of transcription and metabolism,and related host factors,with a focus on the potential pathways and strategies for cccDNA silencing or elimination.

关 键 词：乙型肝炎病毒 DNA 环状 代谢 转录调控 抗病毒策略 

分 类 号：R575.2[医药卫生—消化系统]