肝纤维化相关细胞信号转导通路及潜在治疗策略  

Cell signaling pathways associated with liver fibrosis and potential therapeutic strategies

作　　者：邓羊羊 葛善飞[1] 余燕青[2] 熊英[1] DENG Yangyang;GE Shanfei;YU Yanqing(Department of Infectious Diseases, The First Affiliated Hospital of Nanchang University, Nanchang 330006, China)

机构地区：[1]南昌大学第一附属医院感染性疾病科,南昌330006 [2]南昌大学第一附属医院病理科,南昌330006

出　　处：《临床肝胆病杂志》2020年第5期1141-1145,共5页Journal of Clinical Hepatology

基　　金：国家自然科学基金地区基金项目(81660109)。

摘　　要：肝纤维化是各种病因所致慢性肝损伤而出现的一种病理变化,是以肝星状细胞激活为中心环节,由多种细胞信号转导通路共同参与调控的复杂病变,具有修复和损伤双重性,并最终可能进一步发展为肝硬化、肝衰竭,甚至肝癌。近些年来,肝纤维化相关细胞信号转导通路的基础研究进展迅速,肝纤维化的治疗策略研究也取得一定进展。简要回顾了肝纤维化发生相关的细胞信号转导通路,主要包括JAK/STAT信号通路、NF-κB信号通路、MAPK信号通路、TGFβ1/Smad信号通路、Wnt信号通路、Hedgehog信号通路、Notch信号通路,同时介绍了当前肝纤维化的潜在治疗策略。Liver fibrosis is a chronic liver injury caused by various etiologies and a complex pathological change with the activation of hepatic stellate cells as the central link,and various signaling pathways are involved in the regulation of such complex lesions.It has the dual nature of repair and damage and may eventually progress to liver cirrhosis,liver failure,and even liver cancer.In recent years,rapid progress has been made in the basic research on the cell signal transduction pathways associated with liver fibrosis,and some achievements have been made in the research on the treatment strategy of liver fibrosis.This article briefly reviews the cell signaling pathways associated with the development of liver fibrosis,including the JAK/STAT signaling pathway,the NF-κB signaling pathway,the MAPK signaling pathway,the TGF-signaling 1/Smad signaling pathway,the Wnt signaling pathway,the Hedgehog signaling pathway,and the Notch signaling pathway,and also introduces the potential therapeutic strategies for liver fibrosis at present.

关 键 词：肝硬化 信号传导 治疗学 

分 类 号：R575.2[医药卫生—消化系统]