美沙酮维持治疗对海洛因依赖患者注意偏向的影响  

Effects of methadone maintenance treatment on attention bias in patients with heroin dependence

作　　者：詹同宝[1] 尹良爽 童韦玮 凡春芳 白孝红 程晋波 Zhan Tongbao;Yin Liangshuang;Tong Weiwei;Fan Chunfang;Bai Xiaohong;Cheng Jinbo(Department of Psychology,the Fourth People's Hospital of Huainan,Huainan 232052,China;Department of Psychology,the General Hospital of Anhui Prison,Heifei,Anhui 231001,China)

机构地区：[1]淮南市第四人民医院精神科,安徽省232052 [2]安徽省监狱总医院精神科,合肥231001

出　　处：《中国基层医药》2020年第9期1030-1034,共5页Chinese Journal of Primary Medicine and Pharmacy

基　　金：安徽省淮南市科技创新平台医药卫生子项目(2017A0597)。

摘　　要：目的探讨美沙酮维持治疗(Methadone Maintenance Therapy,MMT)对海洛因依赖患者注意偏向的影响。方法2018年1-9月,选取淮南市第四人民医院MMT门诊的患者(MMT组)38例及淮南市社区的男性健康志愿者32例健康对照(health control,HC)组,均进行情绪词Stroop任务评估,观察比较两组注意偏向的差异。结果在Stroop任务中线索词错误数方面,MMT组错误数低于HC组[0.75(2,5)比1(0,2)],差异有统计学意义(Z=-2.184,P=0.029);MMT组与HC组在点、中性词错误数以及点、中性词、线索词反应时间方面[1(0,4)比1(0,2);3(2,5)比2(2,3);(1055.14±303.50)ms比(985.40±173.71)ms,(1126.89±347.82)ms比(1022.76±173.62)ms;(1188.53±371.80)ms比(1113.23±225.11)ms],差异均无统计学意义(Z=-1.331,P=0.183;Z=-1.723,P=0.085;t=1.150,P=0.254;t=1.539,P=0.129;t=1.001,P=0.320);美沙酮剂量及服药时间长短组间注意偏向比较差异均无统计学意义(均P>0.05)。结论MMT患者对海洛因线索存在注意偏向,MMT时间和剂量对患者注意偏向并无显著影响。Objective To explore the differences of attention bias performance between patients with heroin dependence in methadone maintenance treatment(MMT)and healthy controls.Methods A total of 38 heroin dependent patients in the Fourth People's Hospital of Huainan from January 2018 to September 2018 were selected as MMTgroup,and 32 gender-and age-matched healthy controls were selected as healthy control(HC)group.The attention bias was evaluated by Emotional Stroop Task,and the difference between the two groups was compared.Results The error number of the herion-related words in Emotional Stroop Task of MMT group was lower than that of HC group[0.75(2,5)vs.1(0,2)],the difference was statistically significant(Z=-2.184,P=0.029).The number of errors in point and neutral words and reaction time of point,neutral word and clue word had no statistically significant differences between MMT group and HC group[1(0,4)vs.1(0,2);3(2,5)vs.2(2,3);(1055.14±303.50)ms vs.(985.40±173.71)ms,(1126.89±347.82)ms vs.(1022.76±173.62)ms;(1188.53±371.80)ms vs.(1113.23±225.11)ms](Z=-1.331,P=0.183;Z=-1.723,P=0.085;t=1.150,P=0.254;t=1.539,P=0.129;t=1.001,P=0.320).There were no statistically significant differences in attention bias influenced by the dosage and duration of methadone between MMT group and HC group(all P>0.05).Conclusion These results demonstrate that heroin dependence patients in MMT have attentional bias in heroin-related words.Methadone has no effect on attention bias in patients with heroin dependence during maintenance treatment intervention.

关 键 词：海洛因依赖 美沙酮 注意 认知 焦虑 抑郁 STROOP任务 

分 类 号：R74[医药卫生—神经病学与精神病学]