无抽搐电休克疗法联合丙戊酸钠缓释片对双相情感障碍躁狂发作患者认知功能及预后的影响  

Effects of non-convulsive electroconvulsive therapy combined with sodium valproate sustained-release tablets on cognitive function and prognosis of bipolar disorder patients with manic episode

作　　者：陈晓燕 曹峰 Chen Xiaoyan;Cao Feng(Department of Clinical Pharmacy,the Seventh People's Hospital of Shaoxing,Shaoxing,Zhejiang 312000,China;Department of Psychiatry,the Seventh People's Hospital of Shaoxing,Shaoxing,Zhejiang 312000,China)

机构地区：[1]绍兴市第七人民医院临床药学科,浙江省312000 [2]绍兴市第七人民医院精神科,浙江省312000

出　　处：《中国基层医药》2020年第9期1040-1045,共6页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的探讨无抽搐电休克联合丙戊酸钠缓释片对双相情感障碍躁狂发作患者认知功能及预后的影响。方法选择2016年1月至2019年1月绍兴市第七人民医院收治的躁狂发作的双相情感障碍患者100例为研究对象,按照随机数字表法将100例患者分为联合组(50例)和对照组(50例)。对照组患者口服丙戊酸钠缓释片,联合组患者则联合无抽搐电休克进行治疗。观察、比较两组患者的精神状况、认知功能以及预后情况等。结果两组治疗前的简明精神病评定量表(BPRS)、Bech-Rafaelsen躁狂量表(BRMS)评分差异均无统计学意义(均P>0.05);联合组治疗4周后的BPRS、BRMS评分分别为(19.18±3.16)分、(6.16±2.71)分,均明显低于对照组的(22.23±3.73)分、(8.23±3.03)分,差异均有统计学意义(t=4.411、3.600,P=0.000、0.000);治疗4周后,联合组的完成分类数为(3.23±0.58),明显高于对照组的(3.23±0.58),错误应答数、持续应答数和持续错误数分别为(31.49±8.18)、(21.66±7.48)、(10.47±2.88),均明显低于对照组的(43.26±10.32)、(26.41±9.16)、(15.12±3.43),差异均有统计学意义(t=5.029、6.320、2.840、7.341,P=0.000、0.000、0.005、0.000);联合组韦氏成人智力量表评分中的言语智商、操作智商、智商评分分别为(108.81±13.66)分、(107.41±15.23)分、(109.71±16.23)分,均明显高于对照组的(101.55±10.08)分、(100.94±13.78)分、(102.48±14.64)分,差异均有统计学意义(t=3.023、2.229、2.339,P=0.、0.028、0.021);联合组韦氏记忆量表评分中长时记忆、短时记忆、瞬时记忆、记忆商数分别为(41.55±6.12)分、(58.16±7.16)分、(13.55±2.71)分、(104.46±11.69)分,均明显高于对照组的(38.23±5.28)分、(49.11±5.31)分、(12.06±2.19)分、(98.71±9.51)分,差异均有统计学意义(t=2.904、7.178、3.023、2.698,P=0.004、0.000、0.003、0.008);联合组患者的起效时间、约束时间、住院时间分别为(16.44±5.06)d、(30.71±9.27)h、(49.54±9.28)dObjective To explore the effects of non-convulsive electroconvulsive therapy combined with sodium valproate sustained-release tablets on cognitive function and prognosis of bipolar disorder patients with manic episode.Methods From January 2016 to January 2019,100 patients with bipolar disorder manic episode admitted to the Seventh People's Hospital of Shaoxing were studied.According to the random number table method,100 patients were divided into combined group(50 cases)and control group(50 cases).The patients in the control group were treated with valproate sustained-release tablets,and the patients in the combined group were treated with valproate sustained-release tablets combined with convulsive-free electroconvulsive therapy.The mental status,cognitive function and prognosis of the two groups were observed and compared.Results There were no statistically significant differences in the scores of Brief Psychiatric Rating Scale(BPRS),Bech-Rafaelsen mania scale(BRMS)between the two groups before treatment(all P>0.05).The scores of BPRS and BRMS in the combined group after 4 weeks of treatment were(19.18±3.16)points,(6.16±2.71)points,respectively,which were significantly lower than those in the control group[(22.23±3.73)points,(8.23±3.03)points](t=4.411,3.600,P=0.000,0.000).After 4 weeks of treatment,the number of completed classification in the combined group was(3.23±0.58),which was significantly higher than that in the control group(3.23±0.58),and the number of errors,persistent responses and persistent errors in the combined group were(31.49±8.18),(21.66±7.48),(10.47±2.88),which were significantly lower than those in the control group[(43.26±10.32),(26.41±9.16),(15.12±3.43)],the differences were statistically significant(t=5.029,6.320,2.840,7.341,P=0.000,0.000,0.005,0.000).The verbal intelligence quotient,operational intelligence quotient and IQ score of WAIS-RC scale in the combined group were(108.81±13.66)points,(107.41±15.23)points,(109.71±16.23)points,respectively,which were significantly h

关 键 词：精神分裂症 双相情感障碍 电休克治疗 简明精神病评定量表 Bech-Rafaelsen躁狂量表 威斯康星卡片分类测验 韦氏成人智力量表 韦氏记忆量表 丙戊酸钠 

分 类 号：R74[医药卫生—神经病学与精神病学]