微波热疗联合放射治疗晚期胃癌患者临床疗效、预后与医疗器械不良事件分析  

Analysis on the clinical effect, adverse events of medical devices and prognosis of microwave hyperthermia combined with radiotherapy in the treatment of patients with advanced gastric cancer

作　　者：陈明晓[1] 刘楷东 张继东[1] Chen Mingxiao;Liu Kaidong;Zhang Jidong(the Second Ward of Abdominal and Pelvic Radiotherapy,Cancer Hospital of Shanxi Province,Taiyuan,Shanxi 030013,China)

机构地区：[1]山西省肿瘤医院放疗腹盆二病区,太原030013

出　　处：《中国基层医药》2020年第9期1106-1110,共5页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的探讨微波热疗联合放射治疗晚期胃癌患者临床疗效、不良事件与预后。方法选择2017年5月至2019年5月山西省肿瘤医院收治晚期胃癌患者80例,按照随机数字表法分为两组,每组40例。对照组给予放射治疗,研究组在对照组基础上使用微波热疗治疗。对两组临床疗效、不良事件与预后进行比较。结果研究组总有效率为90.00%(36/40),明显高于对照组的70.00%(28/40)(χ^2=5.000,P<0.05)。研究组治疗后肿瘤直径低于对照组[(2.30±0.20)cm比(2.66±0.23)cm,t=7.470,P<0.05]。研究组不良事件发生率为10.00%(4/40),明显低于对照组的27.50%(11/40)(χ^2=4.020,P<0.05)。研究组患者生理机能[(74.17±5.23)分]、躯体疼痛[(73.07±5.49)分]、一般健康[(75.13±5.50)分]、精神状态[(75.16±3.27)分]与社会功能[(75.49±3.24)分]等生活质量评分均优于对照组[(62.55±5.70)分、(63.24±6.37)分、(65.72±5.30)分、(63.05±2.49)分、(65.34±4.59)分](t=9.500、7.393、7.791、18.634、11.425,均P<0.05)。结论临床采用微波热疗联合放射治疗晚期胃癌患者,降低医疗器械不良事件,提高生活质量,临床效果显著,具一定临床使用价值。Objective To analyze the clinical effect,adverse events and prognosis of microwave hyperthermia combined with radiotherapy in the treatment of patients with advanced gastric cancer.Methods From May 2017 to May 2019,80 patients with advanced gastric cancer admitted to Cancer Hospital of Shanxi Province were selected and divided into two groups according to the random digital table method,with 40 cases in each group.The control group was treated with radiotherapy,and the study group was treated with microwave hyperthermia on the basis of the control group.The clinical efficacy,adverse events and prognosis of the two groups were compared.Results The total effective rate in the study group was 90.00%(36/40),which was higher than 70.00%(28/40)in the control group(χ^2=5.000,P<0.05).After treatment,the diameter of tumor in the study group was lower than that in the control group[(2.30±0.20)cm vs.(2.66±0.23)cm,t=7.470,P<0.05].The incidence of adverse events in the study group was 10.00%(4/40),which was lower than 27.50%(11/40)in the control group(χ^2=4.020,P<0.05).The quality of life scores of the study group[physiological function(74.17±5.23)points,physical pain(73.07±5.49)points,general health(75.13±5.50)points,mental state(75.16±3.27)points and social function(75.49±3.24)points]were better than those of the control group[(62.55±5.70)points,(63.24±6.37)points,(65.72±5.30)points,(63.05±2.49)points,(65.34±4.59)points](t=9.500,7.393,7.791,18.634,11.425,all P<0.05).Conclusion Microwave hyperthermia combined with radiotherapy can reduce adverse events and improve the quality of life of patients with advanced gastric cancer.

关 键 词：胃肿瘤 微波 透热疗法 放射疗法 预后 生活质量 

分 类 号：R735[医药卫生—肿瘤]