解郁丸联合米氮平治疗难治性抑郁症的临床观察  

Clinical Observation of Jieyu Pill Combined with Mirtazapine in Treating Refractory Depression

作　　者：叶海森[1] 范芳秀[1] 陈曦[1] 李韧娇 曹慧 YE Haisen;FAN Fangxiu;CHEN Xi;LI Renjiao;CAO hui(Department of Psychiatry,Hunan Brain Hospital,Changsha 410007,China)

机构地区：[1]湖南省脑科医院精神科,长沙410007

出　　处：《世界中医药》2020年第10期1454-1457,共4页World Chinese Medicine

基　　金：湖南省卫生健康委科研项目(C2019039)。

摘　　要：目的:探讨解郁丸联合米氮平对难治性抑郁症患者NE、BDNF及社会功能的影响。方法:选取2017年7月至2019年7月湖南省脑科医院收治的难治性抑郁症患者80例作为研究对象,按照随机数字表法随机分为对照组(n=38)和观察组(n=42)。对照组给予米氮平片治疗,观察组在此基础上给予解郁丸治疗,2组均治疗8周。比较2组治疗后的临床疗效;比较2组治疗前后血清NE、BDNF水平、社会功能及生命质量;统计2组治疗期间的不良反应发生率。结果:观察组总有效率为88.10%,高于对照组的68.42%(P<0.05)。与治疗前比,治疗8周后,2组血清NE、BDNF水平均升高,且观察组高于对照组(P<0.05);2组HAMD、SDSS评分均降低,且观察组低于对照组(P<0.05);2组ADL评分均升高,且观察组高于对照组(P<0.05)。观察组不良反应发生率为11.90%,低于对照组的23.68%(P<0.05)。结论:解郁丸联合米氮平治疗难治性抑郁症,可明显升高患者血清NE、BDNF水平,改善其抑郁情绪,并能提高患者社会功能,改善其生命质量,继而可提高疗效,且安全性较好。Objective:To explore the effects of Jieyu Pill combined with mirtazapine on the NE and BDNF and social function in patients with intractable depression.Methods:A total of 80 patients with intractable depression treated in Hunan Brain Hospital between July 2017 and July 2019 were selected as the study objects and were divided into a control group(n=38)and an observation group(n=42)by random number table method.The control group was given mirtazapine tablets,and the observation group was given Jieyu Pill for treatment.Both groups were treated continuously for 8 weeks.The clinical efficacy of the 2 groups after treatment were compared;the levels of serum NE,BDNF,social function,and quality of life before and after treatment between the 2 groups were compared;and the incidence of adverse reactions during the 2 groups were calculated.Results:The total effective rate in the observation group was 88.10%,which was higher than 68.42%in the control group(P<0.05).Compared with those before treatment,after 8 weeks of treatment,the levels of serum NE and BDNF in the 2 groups increased,and the observation group was higher than the control group(P<0.05);the scores of HAMD and SDSS in both groups decreased,and the observation group was obviously lower in the control group(P<0.05);the scores of ADL in both groups increased,and those in the observation group was higher than those in control group(P<0.05).The incidence of adverse reactions in the observation group was 11.90%,which was lower than 23.68%in the control group(P<0.05).Conclusion:Jieyu Pill combined with mirtazapine in the treatment of intractable depression can significantly increase the the levels of serum NE and BDNF in patients,improve the patient′s depression,thereby improving the social function of patients,improving their quality of life,and improving patient clinical efficacy,with better safety.

关 键 词：抑郁症 解郁丸 米氮平片 社会功能 生命质量 

分 类 号：R749.4[医药卫生—神经病学与精神病学] R2-031[医药卫生—临床医学]