TCT联合CEA、AFP、CRP检测对宫颈癌的诊断价值  

Diagnostic Value of TCT Combined with CEA,AFP and CRP in Cervical Cancer

作　　者：陈静华[1] 韦励[1] 陈文婷 黄巧如 CHEN Jinghua;WEI Li;CHEN Wenting(Dongguan People's Hospital,Dongguan,523000)

机构地区：[1]东莞市人民医院,523000

出　　处：《实用癌症杂志》2020年第6期1023-1026,1039,共5页The Practical Journal of Cancer

摘　　要：目的探讨TCT联合CEA、AFP、CRP检测在对宫颈癌的诊断中的价值。方法选取宫颈病变的患者共80例,随机将其分为对照组和试验组,每组各40例。对照组仅采取TCT进行检测,而观察组采取TCT联合CEA、AFP、CRP进行检测。TCT检测是借助亚光医用电子技术有限公司提供的LCT-3500(R)液基细胞超薄制片机进行检测;CEA和CRP是应用电化学发光免疫分析仪检测人空腹静脉血,检测仪器为深圳新产业MAGLUMI-4000全自动电化学发光分析仪,AFP是应用酶联免疫吸附法检测人空腹静脉血,所用试剂盒由浙江杭州辉图生物科技有限公司提供。将两种检测方法的阳性检测情况与组织病理活检结果进行比较;将试验组中宫颈癌患者与正常人血清CEA,AFP,CRP的水平进行比较;将单独检测及联合检测的诊断效能评估进行比较(灵敏度,特异度等指标)。结果在试验组的40例被检人员中,检测出阳性的有26例,而组织病理活检结果为17例,阳性符合率为65.38%;在对照组的40例被检人员中,检测出阳性的有31例,而组织病理活检结果为15例,阳性符合率为48.39%;试验组阳性符合率显著高于对照组(P<0.05)。试验组宫颈癌患者中血清CEA、AFP、CRP水平均显著高于正常人水平(P<0.05)。TCT联合CEA、AFP、CRP检测的AUC,敏感度、特异度、阳性预测值、阴性预测值均显著高于TCT检测(P<0.05)。结论TCT联合CEA、AFP、CRP检测在对宫颈癌的诊断中,可有效提高准确率,提高女性的生存质量。Objective To explore the value of TCT combined with CEA,AFP and CRP in the diagnosis of cervical cancer.Methods 80 patients with cervical lesions were randomly divided into the control group and the experimental group with 40 cases in each group.The control group was 29~63 years old,with an average age of(39.4±5.7)years old.The age of the experimental group was 30~65 years old,with an average age of(40.3±6.2).There was no statistically significant difference between the 2 groups in the comparison of general data(P>0.05),suggesting comparability.Only TCT was used in the control group,while TCT combined with CEA,AFP and CRP was used in the observation group.TCT test is conducted by using lct-3500(R)ultra-thin film-making machine provided by sub-optical medical electronics technology co.,LTD.CEA and CRP are used to detect fasting venous blood of human by electrochemical luminescence immunoanalyzer.The detection instrument is maglumi-4000 automatic electrochemical luminescence analyzer,a new industry in Shenzhen.AFP is used to detect fasting venous blood of human by enzyme-linked immunosorbent method.The positive test results of the 2 methods were compared with the pathological biopsy results.The serum CEA,AFP and CRP levels of cervical cancer patients in the test group were compared with those of normal subjects.The diagnostic efficacy of single and combined tests was compared(sensitivity,specificity,etc.).Results Among the 40 subjects in the test group,26 were positive,while the histopathological biopsy results were 17,with a positive coincidence rate of 65.38%.Among the 40 patients in the control group,31 were positive,while the pathological biopsy results were 15,with a positive coincidence rate of 48.39%.The positive coincidence rate of the experimental group was significantly higher than that of the control group(P<0.05).Serum CEA,AFP and CRP levels in patients with cervical cancer in the experimental group were significantly higher than those in normal patients(P<0.05).The AUC,sensitivity,specificity,positiv

关 键 词：液基薄层细胞检测 CEA AFP CRP 联合检测 宫颈癌 诊断价值 

分 类 号：R737.33[医药卫生—肿瘤]