Clinical diagnosis and management of pancreatic mucinous cystadenoma and cystadenocarcinoma:Single-center experience with 82 patients  

作　　者：Zhi-Ming Zhao Nan Jiang Yuan-Xing Gao Zhu-Zeng Yin Guo-Dong Zhao Xiang-Long Tan Yong Xu Rong Liu 

机构地区：[1]Second Department of Hepatopancreatobiliary Surgery,The First Medical Center of Chinese PLA General Hospital,Beijing 100853,China

出　　处：《World Journal of Gastrointestinal Oncology》2020年第6期642-650,共9页世界胃肠肿瘤学杂志（英文版）（电子版）

摘　　要：BACKGROUND Mucinous cystic neoplasm(MCN)of the pancreas is characterized by mucinproducing columnar epithelium and dense ovarian-type stroma and at risk for malignant transformation.Early diagnosis and treatment of MCN are particularly important.AIM To investigate the clinical characteristics of and management strategies for pancreatic mucinous cystadenoma(MCA)and mucinous cystadenocarcinoma(MCC).METHODS The clinical and pathological data of 82 patients with pancreatic MCA and MCC who underwent surgical resection at our department between April 2015 and March 2019 were retrospectively analyzed.RESULTS Of the 82 patients included in this study,70 had MCA and 12 had MCC.Tumor size of MCC was larger than that of MCA(P=0.049).Age and serum levels of tumor markers carcinoembryonic antigen(CEA),carbohydrate antigen(CA)19-9,and CA12-5 were significantly higher in MCC than in MCA patients(P=0.005,0.026,and 0.037,respectively).MCA tumor size was positively correlated with serum CA19-9 levels(r=0.389,P=0.001).Compared with MCC,MCA had a higher minimally invasive surgery rate(P=0.014).In the MCA group,the rate of major complications was 5.7%and that of clinically relevant pancreatic fistula was 8.6%;the corresponding rates in the MCC group were 16.7%and 16.7%,respectively.CONCLUSION Tumor size,age,and serum CEA,CA19-9,and CA12-5 levels may contribute to management of patients with MCN.Surgical resection is the primary treatment modality for MCC and MCA.

关 键 词：Pancreatic neoplasms Mucinous cystadenoma Mucinous cystadenocarcinoma Biochemical indexes DIAGNOSIS SURGERY 

分 类 号：R735.9[医药卫生—肿瘤]