Nutrition in alcohol-related liver disease:Physiopathology and management  

作　　者：Umair Kamran Jennifer Towey Amardeep Khanna Abhishek Chauhan Neil Rajoriya Andrew Holt 

机构地区：[1]The Liver Unit,Queen Elizabeth Hospital Birmingham,Birmingham B152GW,United Kingdom [2]Department of Dietetics,Queen Elizabeth Hospital Birmingham,Birmingham B152GW,United Kingdom [3]Centre for Liver Research,Institute of Immunology and Inflammation,and National Institute for Health Research(NIHR)Birmingham Biomedical Research Centre,The Medical School,University of Birmingham,Birmingham B152TT,United Kingdom

出　　处：《World Journal of Gastroenterology》2020年第22期2916-2930,共15页世界胃肠病学杂志（英文版）

摘　　要：Malnutrition encompassing both macro-and micro-nutrient deficiency,remains one of the most frequent complications of alcohol-related liver disease(ArLD).Protein-energy malnutrition can cause significant complications including sarcopenia,frailty and immunodepression in cirrhotic patients.Malnutrition reduces patient’s survival and negatively affects the quality of life of individuals with ArLD.Moreover,nutritional deficit increases the likelihood of hepatic decompensation in cirrhosis.Prompt recognition of at-risk individuals,early diagnosis and treatment of malnutrition remains a key component of ArLD management.In this review,we describe the pathophysiology of malnutrition in ArLD,review the screening tools available for nutritional assessment and discuss nutritional management strategies relevant to the different stages of ArLD,ranging from acute alcoholic hepatitis through to decompensated end stage liver disease.

关 键 词：MALNUTRITION SARCOPENIA Alcohol-related liver disease Nutritional assessment Nutrition support MICRONUTRIENTS 

分 类 号：R575[医药卫生—消化系统]