T4 cervical esophageal cancer cured with modern chemoradiotherapy: A case report  

作　　者：Chia Ching Lee Chong Ming Yeo Wee Khoon Ng Akash Verma Jeremy CS Tey 

机构地区：[1]Department of Radiation Oncology,National University Cancer Institute,National University Hospital,Tan Tock Seng Hospital,Singapore 119228,Singapore [2]Department of Medical Oncology,Tan Tock Seng Hospital,Singapore 308433,Singapore [3]Department of Gastroenterology and Hepatology,Tan Tock Seng Hospital,Singapore 308433,Singapore [4]Department of Respiratory and Critical Care Medicine,Tan Tock Seng Hospital,Singapore 308433,Singapore

出　　处：《World Journal of Clinical Cases》2020年第10期1950-1957,共8页世界临床病例杂志

摘　　要：BACKGROUND T4 esophageal cancer portends a poor prognosis,particularly when it is complicated by a tracheoesophageal fistula(TEF)either resulting from disease or occurring as a complication of treatment.Patients with TEF that occurs during treatment are commonly treated with palliative intent because fistula-associated treatment complications such as aspiration pneumonia and mediastinitis are associated with high morbidity and mortality.To date,there is no clear evidence on the optimal treatment of T4 esophageal cancer,particularly when a TEF formation occurs.CASE SUMMARY A 67-year-old gentleman who presented with dysphagia and weight loss.Endoscopy and imaging revealed a T4N1M0 cervical esophageal squamous cell carcinoma.He received image-guided intensity-modulated radiation therapy,with concurrent weekly carboplatin(area under curve 2 mg/mL per minute)and paclitaxel(50 mg/m2 of body surface area).One week after treatment initiation(16.2 Gy thus far),he developed cough on swallowing.A TEF was detected on image-guided radiation therapy using cone-beam computed tomography during the treatment course,for which a tracheal stent was inserted.After discussing the risks and morbidity of continuing treatment,he resumed chemoradiotherapy with an additional radiation dose of 45 Gy in 25 fractions.Three months after completion of chemoradiotherapy,he developed an esophageal stricture that required esophageal stenting and dilatation.The patient remains cancer-free at two year on follow-up.Complete response of esophageal cancer was evident on post-treatment endoscopy and computed tomography imaging,with successful closure of TEF.CONCLUSION This case highlights that successful curative treatment for esophageal cancer complicated by a TEF is possible using novel chemotherapeutic regimens and modern radiation technologies.

关 键 词：Esophageal cancer CHEMORADIOTHERAPY FISTULA STENTING T4 Case report 

分 类 号：R737.33[医药卫生—肿瘤]