Cytapheresis for pyoderma gangrenosum associated with inflammatory bowel disease:A review of current status  

作　　者：Kentaro Tominaga Kenya Kamimura Hiroki Sato Masayoshi Ko Yuzo Kawata Takeshi Mizusawa Junji Yokoyama Shuji Terai 

机构地区：[1]Division of Gastroenterology and Hepatology,Graduate School of Medical and Dental Sciences,Niigata University,Niigata 951-8510,Japan

出　　处：《World Journal of Clinical Cases》2020年第11期2092-2101,共10页世界临床病例杂志

摘　　要：Pyoderma gangrenosum(PG)is a neutrophilic dermatosis clinically characterized by the presence of painful skin ulcerations with erythematous.As it is frequently associated with inflammatory bowel diseases,including ulcerative colitis,gastroenterologists should be familiar with the disease including therapeutic options.Therefore,we have conducted a review focusing on the cytapheresis for PG in cases of inflammatory bowel diseases.A literature search was conducted to extract studies published in the last 20 years,with information on demographics,clinical symptoms,treatment,and the clinical course from a total of 22 cases reported and our recent case.In most patients,cytapheresis was associated with improvement or resolution of PG after failure of conventional therapeutic options such as corticosteroids,antibiotics,immunosuppressive agents and immunoglobulin.Based on the information summarized,cytapheresis is helpful in the majority of patients with PG refractory to medical treatment associated with inflammatory bowel diseases and could be further studied in a multicenter,randomized trial.

关 键 词：Granulocytapheresis Leucocytapheresis CYTAPHERESIS Inflammatory bowel diseases Pyoderma gangrenosum COMPLICATIONS 

分 类 号：R574[医药卫生—消化系统] R753[医药卫生—内科学]