101例老年人口腔念珠菌病临床情况及氟康唑疗效分析  

Clinical analysis of oral candidiasis and the effect of fluconazole in 101 elderly patients

作　　者：马丽娜[1] 汪慧 马小花 米璇 漆明[1] MA Lina;WANG Hui;MA Xiaohua;MI Xuan;QI Ming(The general hospital of Ningeia Medical University.Yinchuan,Ningria,750004,China)

机构地区：[1]宁夏医科大学总医院,宁夏银川750004

出　　处：《新疆医学》2020年第3期265-269,共5页Xinjiang Medical Journal

摘　　要：目的分析101例老年患者口腔念珠菌病临床情况并探讨影响氟康唑疗效的相关因素。方法依据临床表现及实验室检验结果分析101例老年人口腔念珠菌病患者的临床类型、发病原(诱)因;采用氟康唑对患者进行治疗,从佩戴义齿、全身系统疾病、口腔黏膜其他疾病3方面探究影响氟康唑疗效的相关因素。采用百分比分析临床类型、发病原(诱)因及氟康唑疗效,采用χ~2检验对影响氟康唑疗效相关因素进行统计分析,检验水准α=0.05。结果101例老年人口腔念珠菌病患者中男性:女性为1:1.7;临床表现以急性萎缩型(40.59%)、慢性萎缩型(57.42%)为主;68.32%伴有系统性疾病,其中52.17%为糖尿病患者;51.49%伴有黏膜其他病变,其中48.39%为扁平苔藓;57.43%戴用活动义齿;氟康唑疗效:治愈24(23.76%),显效33(32.67%),有效37(36.64%),无效7(6.93%),7例出现耐药现象;佩戴义齿与氟康唑疗效存在关系(P<0.05),系统性疾病、口腔其他疾病无统计学意义(P>0.05)。结论老年人口腔念珠菌病的诱发因素主要与全身系统情况及口腔局部环境有关,氟康唑能够有效治疗老年人口腔念珠菌病,佩戴义齿是影响氟康唑疗效的因素,耐药菌株的出现是氟康唑治疗效果不佳的主要原因。Objective To analyze the clinical characteristics of oral candidiasis in 101 elderly patients and to explore the related factors with the efficacy of fluconazole. Methods 101 cases with oral candidiasis were analyzed according to clinical manifestations and laboratory test. Fluconazole was given to patients, and related factors affecting the efficacy of fluconazole were explored from three aspects including wearing denture, systemic diseases and other diseases of oral mucosa. The percentage analysis were used to analyze with pathogenesis(lure) for clinical types and curative effect of fluconazole. χ~2 inspection was carried out to analyze about the factors influencing the effect of fluconazole and its outcomes, inspection level of alpha = 0.05. Results Among 101 cases undergoing oral candidiasis, the proportion of male and female patients were 1:1.7. The clinical manifestations included mainly acute atrophy(40.59%)and chronic atrophy(57.42%). 68.32% cases were accompanied by systemic diseases, among which 52.17% were diabetic patients.51.49% were accompanied by other mucosal lesions, among them, 48.39% were lichen planus. 57.43% cases wore removable denture;About efficacy of Fluconazole, there were 24 cases(23.76%)who were cured. 33 cases(32.67%)were markedly effective, and there were37 cases(36.64%)were effective. Ineffective results happened in 7 cases(6.93%). 7 cases got drug tolerance;There was dependency between the efficacy of fluconazole and the wearing of denture(P < 0.05), but systemic diseases and other oral diseases had no effect on the efficacy of fluconazole(P > 0.05). Conclusion Oral candidiasis in the elderly patients are mainly related to systemic conditions and local oral environment. Fluconazole can effectively treat oral candidiasis in the elderly, and wearing dentures can affect the efficacy of fluconazole. The emergence of drug-resistant strains is the main reason for the poor therapeutic effect of fluconazole.

关 键 词：老年人 口腔念珠菌病 病因 氟康唑 疗效 

分 类 号：R781.54[医药卫生—口腔医学]